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基于适体传感器的赭曲霉毒素 A 的超灵敏检测。

Ultrasensitive detection of ochratoxin A using aptasensors.

机构信息

Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Research Institute of Sciences and New Technology, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Biosens Bioelectron. 2017 Dec 15;98:168-179. doi: 10.1016/j.bios.2017.06.055. Epub 2017 Jun 27.

Abstract

Regarding teratogenic, carcinogenic, and immunotoxic nature of ochratoxin A (OTA), selective and sensitive monitoring of this molecule in food samples is of great importance. In recent years, various methods have been introduced for detection of OTA. However, they are usually time-consuming, labor-intensive and expensive. Therefore, these parameters limited their usage. The emerging method of detection, aptasensor, has attracted more attention for OTA detection, due to distinctive advantages including high sensitivity, selectivity and simplicity. In this review, the new developed aptasensors for detection of OTA have been investigated. We also highlighted advantages and disadvantages of different types of OTA aptasensors. This review also takes into consideration the goal to find out which designs are the most rational ones for highly sensitive detection of OTA.

摘要

关于赭曲霉毒素 A(OTA)的致畸、致癌和免疫毒性,对食品样本中这种分子进行选择性和敏感的监测非常重要。近年来,已经引入了各种方法来检测 OTA。然而,它们通常耗时、劳动密集且昂贵。因此,这些参数限制了它们的使用。新兴的检测方法,适配体传感器,由于具有高灵敏度、选择性和简单性等独特优势,引起了人们对 OTA 检测的更多关注。在这篇综述中,研究了新开发的用于检测 OTA 的适配体传感器。我们还强调了不同类型的 OTA 适配体传感器的优缺点。本综述还考虑了旨在找出最合理设计以实现 OTA 高灵敏度检测的目标。

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