Sirin Mumtaz C, Agus Neval, Yilmaz Nisel, Bayram Arzu, Derici Yeser K, Samlioglu Pinar, Hanci Sevgi Y, Dogan Guliz
Department of Medical Microbiology, Tepecik Training and Research Hospital, Izmir, Turkey. E-mail.
Saudi Med J. 2017 Jul;38(7):727-732. doi: 10.15537/smj.2017.7.18182.
To determine the seroprevalence of Toxoplasma gondii (T. gondii), Rubella virus, and Cytomegalovirus (CMV) among pregnant women in Izmir, Turkey.
Medical records of pregnant women attending Izmir Tepecik Training and Research Hospital, Izmir, Turkey between January 2014 and January 2016 were analyzed in this retrospective cross-sectional study. The 7513 T. gondii IgM/IgG results, 7189 Rubella IgM/IgG results, 906 CMV IgM/IgG results and 146 avidity test results were evaluated. Specific IgM and IgG antibodies were detected by an automated chemiluminescent enzyme immunoassay method. Immunoglobulin G avidity tests were performed using a multiparametric immunoassay system.
The rates of IgG positivity for T. gondii was 32.3%, Rubella virus 93.5%, and CMV 98.9%. Immunoglobulin M antibodies were found to be positive in 138 (1.9%) cases for T. gondii, 88 (1.2%) cases for Rubella, and 14 (1.5%) cases for CMV. Avidity tests were ordered from 146 of 218 patients who were found both IgM and IgG positive. Among 146 patients, 6 patients had a low avidity index (all for T. gondii), 11 patients showed borderline avidity, and 129 patients revealed high avidity.
In our region, whereas the rates of IgG positivity for Rubella and CMV are high, most pregnant women were susceptible to T. gondii infections. In order to enhance the reliability of the serological diagnosis, avidity tests should be performed in all IgM positivities detected together with IgG positivity.
确定土耳其伊兹密尔孕妇中弓形虫、风疹病毒和巨细胞病毒（CMV）的血清阳性率。
在这项回顾性横断面研究中，分析了2014年1月至2016年1月期间在土耳其伊兹密尔Tepecik培训与研究医院就诊的孕妇的病历。评估了7513份弓形虫IgM/IgG检测结果、7189份风疹IgM/IgG检测结果、906份CMV IgM/IgG检测结果和146份亲和力检测结果。采用自动化化学发光酶免疫分析法检测特异性IgM和IgG抗体。使用多参数免疫分析系统进行免疫球蛋白G亲和力检测。
弓形虫IgG阳性率为32.3%，风疹病毒为93.5%，CMV为98.9%。发现弓形虫IgM抗体阳性138例（1.9%），风疹IgM抗体阳性88例（1.2%），CMV IgM抗体阳性14例（1.5%）。对218例同时检测出IgM和IgG阳性的患者中的146例进行了亲和力检测。在146例患者中，6例亲和力指数较低（均为弓形虫），11例亲和力处于临界值，129例亲和力较高。
在我们地区，风疹和CMV的IgG阳性率较高，而大多数孕妇易感染弓形虫。为提高血清学诊断的可靠性，对于所有同时检测出IgM阳性和IgG阳性的情况，均应进行亲和力检测。
