De Paschale Massimo, Agrappi Carlo, Manco Maria Teresa, Paganini Alessia, Clerici Pierangelo
Microbiology Unit, Hospital of Legnano (Milan), Via Candiani 2, 20025 Legnano (MI), Italy.
Infect Dis Obstet Gynecol. 2009;2009:206505. doi: 10.1155/2009/206505. Epub 2009 Jul 26.
The fetal consequences of CMV infection make it one of the most serious infections contracted during pregnancy, but the scientific community is divided over the proposed implementation of preventive screening for anti-CMV antibodies. The aim of this study was to assess the incidence and risk of infection during pregnancy in 2817 women who underwent anti-CMV IgG and IgM antibody screening during the period 2005-2007. The prevalence of anti-CMV IgG antibodies was 68.3% (95% CI: 66.6-70.0); the seroconversion rate in the 892 seronegative women was 0.32%; the results of IgG avidity testing revealed an cumulative incidence of 1.4% (95% CI: 0.97-1.83), density incidence of 0.8% (as cases/pregnant woman-trimester) (95% CI: 0.47-1.13), and a risk of infection of 0.5% (95% CI: 0.24-0.76). The screening identified 13 cases of primary infection (84.6% of which occurred in the first trimester of pregnancy). The possibility to identify these cases and consequently to plan appropriate interventions, supports the use of screening during pregnancy, especially in the first trimester when the risk of infection is greater.
巨细胞病毒（CMV）感染对胎儿产生的影响，使其成为孕期感染的最严重感染之一，但科学界对于提议实施的抗CMV抗体预防性筛查存在分歧。本研究旨在评估2005年至2007年期间接受抗CMV IgG和IgM抗体筛查的2817名女性孕期感染的发生率和风险。抗CMV IgG抗体的患病率为68.3%（95%可信区间：66.6 - 70.0）；892名血清阴性女性的血清转化率为0.32%；IgG亲和力检测结果显示累积发病率为1.4%（95%可信区间：0.97 - 1.83），密度发病率为0.8%（以病例/孕妇 - 孕期计）（95%可信区间：0.47 - 1.13），感染风险为0.5%（95%可信区间：0.24 - 0.76）。筛查发现13例原发性感染病例（其中84.6%发生在妊娠早期）。识别这些病例并因此规划适当干预措施的可能性，支持在孕期进行筛查，尤其是在感染风险较高的妊娠早期。
