Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, PO Box 800734, Charlottesville, VA 22901, USA.
Biochem Biophys Res Commun. 2018 May 27;500(1):9-16. doi: 10.1016/j.bbrc.2017.06.192. Epub 2017 Jul 1.
Mitochondrial dynamics are increasingly recognized to play an important role in regulating mitochondrial function in response to diverse stimuli. Given the overlap in the physiological processes influenced by mitochondria and the physiological processes disrupted in tumor cells, we speculate that tumor cells alter mitochondrial shape to promote the tumorigenic phenotype. Here, we briefly review the evidence linking changes in mitochondrial fusion and fission to a number of key tumorigenic processes, including metabolic rewiring, inhibition of cell death, cell migration, cell proliferation and self-renewal capacity. The role of mitochondrial dynamics in tumor growth is an important emerging area of research, a better understanding of which may lead to promising new therapeutic options for the treatment of cancer.
线粒体动力学在调节线粒体功能以响应各种刺激方面的作用越来越受到重视。鉴于受线粒体影响的生理过程和肿瘤细胞中失调的生理过程之间存在重叠，我们推测肿瘤细胞改变线粒体的形状以促进肿瘤发生表型。在这里，我们简要回顾了将线粒体融合和裂变的变化与许多关键的肿瘤发生过程联系起来的证据，包括代谢重编程、抑制细胞死亡、细胞迁移、细胞增殖和自我更新能力。线粒体动力学在肿瘤生长中的作用是一个重要的新兴研究领域，更好地理解这一领域可能为癌症的治疗带来有前途的新治疗选择。
