益康唑与三种常见抗真菌剂对从浅表感染分离出的临床菌株的活性比较。
activity of econazole in comparison with three common antifungal agents against clinical strains isolated from superficial infections.
作者信息
Abastabar M, Shokohi T, Rouhi Kord R, Badali H, Hashemi S J, Ghasemi Z, Ghojoghi A, Baghi N, Abdollahi M, Hosseinpoor S, Rahimi N, Seifi Z, Gholami S, Haghani I, Jabari M R, Pagheh A
机构信息
Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Curr Med Mycol. 2015 Dec;1(4):7-12. doi: 10.18869/acadpub.cmm.1.4.7.
BACKGROUND AND PURPOSE
species are the most common organisms involved in superficial fungal infections, worldwide. Although econazole is among the most frequently used topical formulations for the treatment of candidiasis, no information is available regarding the susceptibility profiles of species in Iran.
MATERIALS AND METHODS
susceptibility of 100 clinical isolates belonging to 6 species from superficial candidiasis of Iran towards to econazole was compared with three other common antifungal agents including itraconazole, fluconazole, and miconazole. Minimum inhibitory concentrations (MICs) values were analyzed according to the Clinical and Laboratory Standards Institute (CLSI) M38-A3 document. All isolates were previously identified to the species level, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on ITS region.
RESULTS
The MIC of econazole, itraconazole, miconazole, and fluconazole were within the range of 0.016-16, 0.032-16, 0.016-16, and 0.25-64 μg/ml, respectively. In general, econazole and miconazole were more active against isolates, compared to the other two agents.
CONCLUSION
The present study demonstrated that for isolates, miconazole and econazole had the best effect, but in non-albicans Candida species, itraconazole and miconazole displayed more activity than other antifungal agents.
背景与目的
在全球范围内，念珠菌属是引起浅表真菌感染最常见的微生物。尽管益康唑是治疗念珠菌病最常用的局部用药制剂之一，但关于伊朗念珠菌属的药敏谱尚无相关信息。
材料与方法
将来自伊朗浅表念珠菌病的100株临床分离株，分属于6个念珠菌物种，对益康唑的敏感性与其他三种常见抗真菌药物（包括伊曲康唑、氟康唑和咪康唑）进行比较。根据临床和实验室标准协会（CLSI）M38 - A3文件分析最低抑菌浓度（MIC）值。所有分离株先前已使用ITS区域的聚合酶链反应 - 限制性片段长度多态性（PCR - RFLP）鉴定到物种水平。
结果
益康唑、伊曲康唑、咪康唑和氟康唑的MIC分别在0.016 - 16、0.032 - 16、0.016 - 16和0.25 - 64μg/ml范围内。总体而言，与其他两种药物相比，益康唑和咪康唑对念珠菌分离株的活性更强。
结论
本研究表明，对于念珠菌分离株，咪康唑和益康唑效果最佳，但在非白色念珠菌物种中，伊曲康唑和咪康唑比其他抗真菌药物表现出更强的活性。
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