O'Boyte C A, Harris D, Barry H, Cullen J H
Psychopharmacology (Berl). 1986;88(2):226-9. doi: 10.1007/BF00652245.
In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious groups by median split of their anxiety scores on the Speilberger State Anxiety Scale at the time of oral medication. Compared with placebo, temazepam significantly attenuated anticipatory anxiety in the High-Anxious group while in the Low-Anxious group no difference was found between the treatments. Preoperative but not intraoperative heart-rate distinguished between the High-Anxious and Low-Anxious groups and neither oral temazepam nor IV diazepam abolished the heart-rate response to the traumatic stages of the surgical procedure. The results are interpreted as providing support in a "real life" human stress setting for Gray's neuropsychological model of anxiety.
在一项随机、双盲、平行组研究中，40名因手术拔除阻生第三磨牙而被转诊的患者接受了以下两种治疗之一：(a)口服替马西泮40毫克，35分钟后静脉注射生理盐水；(b)口服安慰剂，随后静脉注射地西泮10毫克（安定乳剂）。根据口服药物时斯皮尔伯格状态焦虑量表上的焦虑得分中位数，将患者分为高焦虑组和低焦虑组。与安慰剂相比，替马西泮显著减轻了高焦虑组的预期焦虑，而在低焦虑组中，各治疗组之间未发现差异。术前而非术中的心率可区分高焦虑组和低焦虑组，口服替马西泮和静脉注射地西泮均未消除手术创伤阶段的心率反应。这些结果被解释为在“现实生活”的人类应激环境中为格雷的焦虑神经心理学模型提供了支持。
