Popova Milena, Giannopoulou Efstathia, Skalicka-Woźniak Krystyna, Graikou Konstantia, Widelski Jaroslaw, Bankova Vassya, Kalofonos Haralabos, Sivolapenko Gregory, Gaweł-Bęben Katarzyna, Antosiewicz Beata, Chinou Ioanna
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Division of Pharmacognosy and Chemistry of Natural Products, Departments of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Molecules. 2017 Jul 11;22(7):1159. doi: 10.3390/molecules22071159.
In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of (section ) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of -coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of (section ). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95-1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25-1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health.
在本研究中，我们评估了波兰蜂胶的治疗潜力，通过气相色谱-质谱联用仪（GC-MS）进行了化学分析，并确定了其植物来源。已确定了（某属）芽渗出物的典型化学成分，然而，还检测到了酚酸甘油酯，以及异常高含量的对香豆酸和阿魏酸及其苄酯。这些成分是（某属）芽的特征。我们还评估了蜂胶提取物对九种人类癌细胞系的抗增殖作用。此外，还注意到二氯甲烷提取物具有良好的抗菌活性（最低抑菌浓度MIC值为0.95 - 1.24 mg/mL），以及中等程度的抗真菌活性（MIC值为1.25 - 1.40 mg/mL）。波兰蜂胶似乎是抗菌和抗增殖化合物的丰富来源，这证实了它是一种有价值的天然产物，具有改善人类健康的潜力。
