Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 808 Zabrze, Poland.
Evid Based Complement Alternat Med. 2013;2013:731940. doi: 10.1155/2013/731940. Epub 2013 Mar 19.
Epidemiological data support the concept that phenols and polyphenols in diet are safe and nontoxic, and have long-lasting beneficial effects on human health. The potential target for complementary and alternative medicine (CAM) research has been on the discovery of natural compounds that can be used in the prevention and treatment of cancer. Propolis is one of the richest sources of plant phenolics (flavonoids and phenolic acids). The ethanolic extract of propolis (EEP) and its polyphenols possess immunomodulatory, chemopreventive, and antitumor effects. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic to normal cells. Endogenous TRAIL plays a significant role in immunosurveillance and defense against cancer cells. However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new strategies to overcome this resistance. EEP and polyphenols isolated from propolis have been shown to sensitize cancer cells to TRAIL-induced apoptosis. In this paper we demonstrate for the first time the crucial role of the main phenolics isolated from propolis in enhancing TRAIL-mediated death in tumor cells for cancer chemoprevention.
流行病学数据支持这样一种概念，即饮食中的酚类化合物和多酚是安全无毒的，并且对人类健康具有持久的有益作用。补充和替代医学 (CAM) 研究的潜在目标一直是发现可用于预防和治疗癌症的天然化合物。蜂胶是植物类黄酮（类黄酮和酚酸）的最丰富来源之一。蜂胶的乙醇提取物 (EEP) 及其多酚具有免疫调节、化学预防和抗肿瘤作用。肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 是一种天然存在的抗癌剂，它优先诱导癌细胞凋亡，对正常细胞无毒。内源性 TRAIL 在免疫监视和抵御癌细胞方面发挥着重要作用。然而，由于越来越多的肿瘤细胞被报道对 TRAIL 介导的死亡具有抗性，因此开发克服这种抗性的新策略非常重要。已经表明，蜂胶中分离出的 EEP 和多酚能够使癌细胞对 TRAIL 诱导的凋亡敏感。在本文中，我们首次证明了从蜂胶中分离出的主要酚类化合物在增强 TRAIL 介导的肿瘤细胞死亡以进行癌症化学预防方面的关键作用。
