脂滴在自噬过程中保护线粒体。
Lipid Droplets Guard Mitochondria during Autophagy.
机构信息
Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany.
出版信息
Dev Cell. 2017 Jul 10;42(1):1-2. doi: 10.1016/j.devcel.2017.06.018.
PMID:28697329
Abstract
In this issue of Developmental Cell, Nguyen et al. (2017) show that lipid droplets serve a dual purpose during starvation. First, they act as an energy source by supplying fatty acids for mitochondrial β oxidation. Second, they sequester toxic lipids that arise during autophagic degradation of membranous organelles, thereby protecting mitochondria.
摘要
在本期《发育细胞》中，Nguyen 等人（2017 年）表明，脂滴在饥饿期间具有双重作用。首先，它们通过提供脂肪酸用于线粒体β氧化来充当能量来源。其次，它们隔离了自噬降解膜细胞器过程中产生的有毒脂质，从而保护了线粒体。
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