Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, 200072, China.
Sci Rep. 2017 Jul 11;7(1):5076. doi: 10.1038/s41598-017-05281-5.
This study aimed to identify the associated factors for quality measurement (QM) of shear wave speed (SWS) imaging and to validate the additional value of QM in the diagnosis of breast lesions. From September 2014 to February 2015, conventional ultrasound and SWS imaging were performed in 338 women with 361 breast lesions. Binary logistic regression was used to identify associated factors for QM. Sensitivity, specificity and the area under receiver operating characteristic (ROC) curve (AUC) among maximum SWS (SWS ), QM and SWS plus QM (SWS +QM) were compared to validate additional value of QM. Pathology confirmed 263 (72.9%) benign lesions and 98 (27.1%) malignancies. Maximum depth (Odds ratio [OR]: 1.398) and posterior features (OR: 1.206) were identified as independent associated factors for QM. Compared with SWS and QM, the sensitivity of SWS +QM increased from 67.3%, 64.3% to 83.7% whereas the specificity decreased from 90.5%, 72.6% to 65.4% (all P < 0.05). SWS had the highest AUC in comparison with QM and SWS +QM (0.849 vs. 0.685 vs. 0.745; P < 0.05). QM for breast lesions is associated with maximum depth and posterior features. Adding QM to SWS is useful for breast cancer screening and SWS alone is useful for breast cancer differentiation.
本研究旨在确定声触诊组织量化（QTM）剪切波速度（SWS）成像的相关因素，并验证 QTM 在诊断乳腺病变中的附加价值。2014 年 9 月至 2015 年 2 月，对 338 名女性的 361 个乳腺病变进行了常规超声和 SWS 成像检查。采用二项逻辑回归分析确定 QM 的相关因素。比较最大 SWS（SWSmax）、QM 和 SWSmax+QM（SWSmax+QM）之间的敏感性、特异性和接收者操作特征（ROC）曲线下面积（AUC），以验证 QM 的附加价值。病理证实 263 例（72.9%）为良性病变，98 例（27.1%）为恶性病变。最大深度（优势比[OR]：1.398）和后特征（OR：1.206）是 QM 的独立相关因素。与 SWSmax 和 QM 相比，SWSmax+QM 的敏感性从 67.3%、64.3%增加到 83.7%，而特异性从 90.5%、72.6%降低至 65.4%（均 P<0.05）。与 QM 和 SWSmax+QM 相比，SWSmax 的 AUC 最高（0.849 比 0.685 比 0.745；P<0.05）。乳腺病变的 QM 与最大深度和后特征相关。将 QM 添加到 SWSmax 中有助于乳腺癌筛查，而单独使用 SWSmax 有助于乳腺癌的鉴别。
