Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
Biomark Med. 2017 Sep;11(9):761-767. doi: 10.2217/bmm-2017-0144. Epub 2017 Jul 12.
Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI.
PATIENTS & METHODS: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI.
Elevated levels of granzyme B (16.71 ± 7.23 ng/l vs 9.27 ± 3.90 ng/l) correlated with miR-874-3p downregulation (0.20- ± 0.17-fold vs 1.00- ± 0.79-fold) in AMI patients.
Plasma miR-874-3p might target granzyme B and it might be an additional biomarker for AMI.
颗粒酶 B 可诱导急性心肌梗死（AMI）中靶细胞凋亡，并通过搜索 miRNA 数据库被鉴定为 miR-874-3p 的靶标。我们旨在确定颗粒酶 B 和 miR-874-3p 的水平，并检测它们在 AMI 中的相关性或预测能力。
我们测量了 80 例 AMI 患者或 40 例健康对照者血浆中颗粒酶 B 和 miR-874-3p 的水平，并检测了它们对 AMI 的相关性或预测能力。
AMI 患者中颗粒酶 B 水平升高（16.71±7.23ng/l 比 9.27±3.90ng/l）与 miR-874-3p 下调相关（0.20-±0.17 倍比 1.00-±0.79 倍）。
血浆 miR-874-3p 可能靶向颗粒酶 B，它可能是 AMI 的另一个生物标志物。
