Holt P A, Goodall B, Lees E M, Hambling M H
J Hosp Infect. 1986 Jan;7(1):26-33. doi: 10.1016/0195-6701(86)90023-x.
Patients and staff at a hospital for the mentally handicapped were screened for markers of infection with hepatitis B virus. Of 436 patients, 14 (3.2%) were carriers of hepatitis B surface antigen (HBsAg), of whom four were carriers of hepatitis B e antigen (HBeAg) and were considered to be 'infectious'. One-quarter of the patients had markers of hepatitis B infection. Males were four times more likely to have markers than females; and 13 of the 14 carriers of HBsAg were male. Patients with Down's Syndrome (DS) were six times more likely to be HBsAg positive, but were not more likely to have markers of infection than other patients. Phenytoin therapy did not predispose to carriage of HBsAg. Of 439 staff members, 26 (5.9%) had markers of hepatitis B infection. It was not considered that staff were at increased risk of infection with hepatitis B virus at the hospital, and that post-exposure prophylaxis for hepatitis B should continue. It is suggested that patients with DS who are not immune to hepatitis B should be offered immunization.
对一家智障人士医院的患者和工作人员进行了乙肝病毒感染标志物筛查。436名患者中，14人（3.2%）为乙肝表面抗原（HBsAg）携带者，其中4人为乙肝e抗原（HBeAg）携带者，被视为“有传染性”。四分之一的患者有乙肝感染标志物。男性有标志物的可能性是女性的四倍；14名HBsAg携带者中有13名是男性。唐氏综合征（DS）患者HBsAg阳性的可能性是其他患者的六倍，但感染标志物阳性的可能性并不比其他患者更高。苯妥英治疗不会增加HBsAg携带率。439名工作人员中，26人（5.9%）有乙肝感染标志物。医院认为工作人员感染乙肝病毒的风险并未增加，乙肝暴露后预防措施应继续。建议对未对乙肝免疫的DS患者进行免疫接种。
