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用于双模式抗菌表面的模块化方法，结合光开关活性和持续的杀菌释放。

Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release.

机构信息

Department of Chemistry and Centre for Health Technology, University of Pavia, Pavia, Italy.

Department of Physics, University Milano-Bicocca, Milano, Italy.

出版信息

Sci Rep. 2017 Jul 12;7(1):5259. doi: 10.1038/s41598-017-05693-3.

DOI:10.1038/s41598-017-05693-3
PMID:28701753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5507905/
Abstract

Photo-responsive antibacterial surfaces combining both on-demand photo-switchable activity and sustained biocidal release were prepared using sequential chemical grafting of nano-objects with different geometries and functions. The multi-layered coating developed incorporates a monolayer of near-infrared active silica-coated gold nanostars (GNS) decorated by silver nanoparticles (AgNP). This modular approach also enables us to unravel static and photo-activated contributions to the overall antibacterial performance of the surfaces, demonstrating a remarkable synergy between these two mechanisms. Complementary microbiological and imaging evaluations on both planktonic and surface-attached bacteria provided new insights on these distinct but cooperative effects.

摘要

采用顺序化学接枝法将具有不同几何形状和功能的纳米物体进行多层涂层，制备出同时具有按需光切换活性和持续杀菌释放功能的光响应抗菌表面。所开发的多层涂层包含由银纳米粒子（AgNP）修饰的近红外活性二氧化硅包覆的金纳米星（GNS）单层。这种模块化方法还使我们能够揭示表面整体抗菌性能的静态和光激活贡献，展示了这两种机制之间的显著协同作用。对浮游菌和表面附着菌的补充微生物学和成像评估提供了对这些不同但协同作用的新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/427cf1e62dd3/41598_2017_5693_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/37c04a69b0c2/41598_2017_5693_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/881ef3de44d2/41598_2017_5693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/8103555e2737/41598_2017_5693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/b42b3ac35df9/41598_2017_5693_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/427cf1e62dd3/41598_2017_5693_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/37c04a69b0c2/41598_2017_5693_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/410c44b1f9ed/41598_2017_5693_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/881ef3de44d2/41598_2017_5693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/8103555e2737/41598_2017_5693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/b42b3ac35df9/41598_2017_5693_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ccf/5507905/427cf1e62dd3/41598_2017_5693_Fig6_HTML.jpg

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