Mohaghegh Mohammad Ali, Hejazi Seyed Hossein, Ghomashlooyan Mohsen, Kalani Hamed, Mirzaei Farzaneh, Azami Mehdi
Department of Laboratory Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical sciences, Isfahan, Iran.
Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):137-142.
This cross-sectional study aims to assess the prevalence of in hemodialysis patients compared with healthy individuals in central Iran from August 2014 to January 2015.
Cryptosporidiosis is a major cause of acute and persistent diarrhea with significant morbidity and mortality in immunocompromised patients such as those undergoing renal dialysis.
Three stool samples were collected from 330 hemodialysis patients and 150 healthy individuals on 3 consecutive days. The samples were screened for infection using formalin-ether sedimentation and modified Ziehl-Neelsen staining. Demographic variables as well as risk factors were recorded.
Out of 330 dialysis patients and 150 healthy individuals, 10 (3%) and 1 (0.7%) were infected with , respectively. We found statistically significant differences between infection and place of residency, hygiene status, education level, diarrhea, and abdominal pain in the two groups (p<0.05). On the other hand, there was no relationship between infection and sex, contact with domestic animals, fever, vomiting, nausea, flatulence, anorexia, duration of dialysis and underlying disorders in the two groups. Also, there was a statistically significant difference between age and infection in hemodialysis patients (p=0.003). A higher infection rate was observed in patients under 20 years of age.
Risk factors for infection must be controlled. We strongly recommended that stool samples from such patients, especially those with severe or prolonged diarrhea, should be examined with modified Ziehl-Neelsen staining for appropriate and timely treatment.
本横断面研究旨在评估2014年8月至2015年1月期间伊朗中部血液透析患者与健康个体相比的隐孢子虫感染率。
隐孢子虫病是免疫功能低下患者（如接受肾透析的患者）急性和持续性腹泻的主要原因，具有显著的发病率和死亡率。
连续3天从330名血液透析患者和150名健康个体中采集三份粪便样本。使用福尔马林-乙醚沉淀法和改良齐-尼氏染色法对样本进行隐孢子虫感染筛查。记录人口统计学变量以及危险因素。
在330名透析患者和150名健康个体中，分别有10名（3%）和1名（0.7%）感染了隐孢子虫。我们发现两组在感染与居住地点、卫生状况、教育水平、腹泻和腹痛之间存在统计学显著差异（p<0.05）。另一方面，两组在感染与性别、与家畜接触、发热、呕吐、恶心、肠胃胀气、厌食、透析时间和基础疾病之间没有关系。此外，血液透析患者的年龄与感染之间存在统计学显著差异（p=0.003）。20岁以下患者的感染率更高。
必须控制隐孢子虫感染的危险因素。我们强烈建议对这类患者的粪便样本，尤其是那些有严重或长期腹泻的患者，应采用改良齐-尼氏染色法进行检查，以便进行适当和及时的治疗。
