替考拉宁在大鼠局部实验性感染中的活性。

Activity of teicoplanin in localized experimental infections in rats.

作者信息

Arioli V, Berti M, Candiani G

出版信息

J Hosp Infect. 1986 Mar;7 Suppl A:91-9. doi: 10.1016/0195-6701(86)90013-7.

Abstract

We tested the ability of teicoplanin alone and in combination with rifampicin or gentamicin to cure experimental endocarditis and granuloma pouch infections in rats caused by Streptococcus faecalis, Str. sanguis, methicillin-sensitive and -resistant Staphylococcus aureus. Vancomycin and ampicillin were also tested. Teicoplanin was more active than vancomycin and ampicillin. Combinations of teicoplanin with rifampicin or gentamicin were significantly more effective than single drug therapy. These results suggest that teicoplanin could be an interesting alternative to vancomycin in the treatment of serious streptococcal and staphylococcal infections in man.

摘要

我们测试了替考拉宁单独使用以及与利福平或庆大霉素联合使用时，对大鼠由粪链球菌、血链球菌、甲氧西林敏感和耐药金黄色葡萄球菌引起的实验性心内膜炎和肉芽肿袋感染的治愈能力。还测试了万古霉素和氨苄西林。替考拉宁比万古霉素和氨苄西林更具活性。替考拉宁与利福平或庆大霉素联合使用比单一药物治疗显著更有效。这些结果表明，在治疗人类严重的链球菌和葡萄球菌感染时，替考拉宁可能是万古霉素的一个有趣替代药物。