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Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis.替考拉宁在实验性肠球菌心内膜炎中的治疗效果。
Antimicrob Agents Chemother. 1985 Jan;27(1):135-6. doi: 10.1128/AAC.27.1.135.
2
Antimicrobial activity of gentamicin in experimental enterococcal endocarditis.庆大霉素在实验性肠球菌性心内膜炎中的抗菌活性。
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Efficacy of teicoplanin-gentamicin given once a day on the basis of pharmacokinetics in humans for treatment of enterococcal experimental endocarditis.基于人体药代动力学的替考拉宁-庆大霉素每日一次给药方案治疗肠球菌性实验性心内膜炎的疗效。
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Activity of teicoplanin in localized experimental infections in rats.替考拉宁在大鼠局部实验性感染中的活性。
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5
Current perspectives on glycopeptide resistance.糖肽类耐药性的当前观点
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7
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8
The use of a new glycopeptide antibiotic, teicoplanin, in the treatment of bacterial endocarditis.新型糖肽类抗生素替考拉宁在治疗细菌性心内膜炎中的应用。
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Evaluation of teicoplanin for treatment of endocarditis caused by gram-positive cocci in 20 patients.评价替考拉宁治疗20例革兰氏阳性球菌引起的心内膜炎的疗效。
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本文引用的文献

1
A novel mechanism of resistance to penicillin-gentamicin synergism in Streptococcus faecalis.粪肠球菌对青霉素 - 庆大霉素协同作用耐药的一种新机制。
J Infect Dis. 1980 Jan;141(1):81-6. doi: 10.1093/infdis/141.1.81.
2
High-level resistance to gentamicin in clinical isolates of enterococci.肠球菌临床分离株对庆大霉素的高水平耐药性。
J Infect Dis. 1983 Apr;147(4):751-7. doi: 10.1093/infdis/147.4.751.
3
Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci.替考拉宁与万古霉素单独及联合利福平、氨基糖苷类药物对葡萄球菌和肠球菌的体外比较活性
Antimicrob Agents Chemother. 1984 Apr;25(4):411-2. doi: 10.1128/AAC.25.4.411.
4
Comparison of the in vitro activities of teichomycin A2 and vancomycin against staphylococci and enterococci.替考霉素A2与万古霉素对葡萄球菌和肠球菌的体外活性比较。
Antimicrob Agents Chemother. 1982 Mar;21(3):504-5. doi: 10.1128/AAC.21.3.504.
5
Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart.实验性心内膜炎。II. 心脏左侧放置聚乙烯导管后主动脉瓣的葡萄球菌感染。
Yale J Biol Med. 1971 Oct;44(2):206-13.
6
Simple method for elimination of aminoglycosides from serum to permit bioassay of other antimicrobial agents.从血清中去除氨基糖苷类以允许对其他抗菌剂进行生物测定的简单方法。
Antimicrob Agents Chemother. 1977 Aug;12(2):286-7. doi: 10.1128/AAC.12.2.286.
7
Resistance to six aminoglycosidic aminocyclitol antibiotics among enterococci: prevalence, evolution, and relationship to synergism with penicillin.肠球菌对六种氨基糖苷类氨基环醇抗生素的耐药性：流行情况、演变及其与青霉素协同作用的关系。
Antimicrob Agents Chemother. 1977 Sep;12(3):401-5. doi: 10.1128/AAC.12.3.401.
8
Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis.粪肠球菌和屎肠球菌对抗菌协同作用的种属特异性抗性
J Infect Dis. 1979 Aug;140(2):203-8. doi: 10.1093/infdis/140.2.203.

替考拉宁在实验性肠球菌心内膜炎中的治疗效果。

Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis.

作者信息

Sullam P M, Täuber M G, Hackbarth C J, Sande M A

出版信息

Antimicrob Agents Chemother. 1985 Jan;27(1):135-6. doi: 10.1128/AAC.27.1.135.

DOI:10.1128/AAC.27.1.135
PMID:3157344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176220/
Abstract

The antimicrobial activities of teicoplanin and ampicillin, alone and in combination with gentamicin, were compared in experimental Streptococcus faecalis endocarditis. Bacterial titers in vegetations of rabbits treated with teicoplanin were significantly lower than those of untreated controls (P less than 0.01) and were equivalent to titers in ampicillin-treated animals. Gentamicin increased the activities of both drugs to a comparable degree.

摘要

在实验性粪肠球菌心内膜炎中，比较了替考拉宁和氨苄西林单独使用以及与庆大霉素联合使用时的抗菌活性。用替考拉宁治疗的兔子赘生物中的细菌滴度显著低于未治疗的对照组（P小于0.01），且与氨苄西林治疗组动物的滴度相当。庆大霉素使两种药物的活性提高到了相当的程度。