Institute for Bio- and Geosciences I: Biotechnology, Forschungszentrum Jülich GmbH, 52426 Jülich, Germany.
Institute for Bio- and Geosciences I: Biotechnology, Forschungszentrum Jülich GmbH, 52426 Jülich, Germany; Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf in the Forschungszentrum Jülich, 52426 Jülich, Germany.
Bioorg Med Chem. 2018 Apr 1;26(7):1285-1303. doi: 10.1016/j.bmc.2017.06.045. Epub 2017 Jun 28.
Natural compounds are often structurally complex and their synthesis is still highly challenging. The review intends to give an overview on developments in biotechnology and their role for the production of natural products and active agents. In vitro and in vivo methods are presented side by side beginning with rather simple but smart single step conversions, followed by cascade reactions, and finishing with complex bio-, semi- and mutasynthesis endeavours. All the enzymatic approaches do obviously complement traditional synthetic methods; with their particular strengths, the combined repertoire will lead to an increased efficiency in natural product synthesis as well as in providing analogues.
天然化合物通常结构复杂，其合成仍然极具挑战性。本综述旨在概述生物技术的发展及其在天然产物和活性物质生产中的作用。从相对简单但巧妙的单步转化开始，本文并排呈现了体外和体内方法，接着是级联反应，最后是复杂的生物、半合成和突变合成尝试。所有的酶法方法显然都补充了传统的合成方法；通过其特定的优势，组合方法将提高天然产物合成以及提供类似物的效率。
