Mitchell B S, Peel S
Immunology. 1986 Jun;58(2):297-301.
The effects of withdrawal of ovarian hormones and absence of paternal antigens on numbers and distribution of cells expressing Ia, Thy 1.1 or leucocyte-common (LC) antigens in the rat metrial gland have been assessed. The distribution of these markers in non-pregnant uterus at various stages of the oestrous cycle has also been investigated. In primigravid rats at Day 15 of gestation, following ovariectomy on Day 12, marker distribution was not different from that in uninterrupted pregnancy. However, there was a significant increase in the percentage of cells expressing LC antigen, which was not accompanied by an increase in the percentage of the glycoprotein-containing, LC antigen-positive granulated metrial gland (GMG) cells. It was suggested that the accumulation of LC antigen-positive, non-GMG cells might represent the precursors of GMG cells. In deciduomata-bearing rats, there was a significantly lower percentage of LC antigen-bearing cells at Day 13 of pseudopregnancy than in pregnant rats at Day 13, but no difference in the percentages of GMG cells was noted. Cells expressing Ia, LC or Thy 1.1 antigens were detected in the endometrial stroma, surrounding endometrial glands and the luminal epithelium of the non-pregnant uterus.
已评估了卵巢激素撤除和父系抗原缺失对大鼠子宫蜕膜中表达Ia、Thy 1.1或白细胞共同（LC）抗原的细胞数量和分布的影响。还研究了这些标志物在动情周期不同阶段的未孕子宫中的分布。在妊娠第15天的初孕大鼠中，于第12天进行卵巢切除术后，标志物分布与未中断妊娠的情况无异。然而，表达LC抗原的细胞百分比显著增加，且含糖蛋白的LC抗原阳性颗粒状子宫蜕膜（GMG）细胞百分比并未增加。提示LC抗原阳性的非GMG细胞的积累可能代表GMG细胞的前体。在带蜕膜瘤的大鼠中，假孕第13天携带LC抗原的细胞百分比显著低于妊娠第13天的大鼠，但GMG细胞百分比未见差异。在未孕子宫的子宫内膜基质、周围子宫内膜腺体和腔上皮中检测到表达Ia、LC或Thy 1.1抗原的细胞。
