Balavoine Stephanie, Pircher Mathilde, Hoen Bruno, Herrmann-Storck Cecile, Najioullah Fatiha, Madeux Benjamin, Signate Aissatou, Valentino Ruddy, Lannuzel Annie, Saint Louis Magali, Cassadou Sylvie, Cabié André, Schepers Kinda
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Pointe-à-Pitre/Abymes, Pointe-à-Pitre, France.
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Martinique, Martinique, France.
Am J Trop Med Hyg. 2017 Aug;97(2):356-360. doi: 10.4269/ajtmh.15-0753. Epub 2017 Jul 19.
The Guillain-Barré syndrome (GBS) has been reported as a possible complication of acute chikungunya infection. The chikungunya epidemics, which occurred in Martinique and Guadeloupe in 2014, affected 308,000 people in these two islands. GBS occurred during or immediately after acute chikungunya infection in 13 patients (10 men, three women; mean age: 61 years). Median time from acute chikungunya to GBS onset was 9 days. Twelve patients were treated with intravenous polyvalent immunoglobulins, nine of whom improved within 7 days. Five of 13 patients required mechanical ventilation. Two patients with severe GBS died. At 6 months of follow-up, 7/13 achieved a good functional recovery with no or minor residual symptoms. A 2-fold increase in incidence was observed during the year of chikungunya outbreak. This study supports prior reports suggesting that GBS may be a complication of chikungunya.
格林-巴利综合征（GBS）已被报道为急性基孔肯雅热感染可能出现的并发症。2014年在马提尼克岛和瓜德罗普岛发生的基孔肯雅热疫情，使这两个岛屿上的30.8万人受到影响。13名患者（10名男性，3名女性；平均年龄：61岁）在急性基孔肯雅热感染期间或之后不久出现了GBS。从急性基孔肯雅热到GBS发病的中位时间为9天。12名患者接受了静脉注射多价免疫球蛋白治疗，其中9人在7天内病情好转。13名患者中有5人需要机械通气。两名严重GBS患者死亡。在6个月的随访中，13人中有7人实现了良好的功能恢复，没有或仅有轻微残留症状。在基孔肯雅热疫情爆发当年，发病率增加了一倍。这项研究支持了之前的报告，表明GBS可能是基孔肯雅热的一种并发症。
