Vajrabhaya La-Ongthong, Sangalungkarn Vanida, Srisatjaluk Ratchapin, Korsuwannawong Suwanna, Phruksaniyom Chareerut
Endodontic Section, Faculty of Dental Medicine, Rangsit University, Pathum Thani, Thailand.
Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Eur J Dent. 2017 Apr-Jun;11(2):221-225. doi: 10.4103/ejd.ejd_354_16.
This is an study to develop a formulation of a hypochlorite solution for root canal irrigation that lacks a chlorinated odor. The antibacterial effect, tissue dissolution efficacy, and the cytotoxicity of the solution were assessed in cell culture and were compared with those of commercial sodium hypochlorite (NaOCl) solutions.
Trichloroisocyanuric acid (TCA) was used as the source of hypochlorite ions in solution. All required properties of the NaOCl irrigant were evaluated and compared with those of original 2.5% NaOCl solutions currently in use.
Our results revealed that a TCA 3.5% + 1/6 Buffer-1 solution passed the short-term stability test. Moreover, no odor of chlorine gas was detected by three independent observers. The hypochlorite ion content and pH were stable over an incubation period of 4 weeks. The new solution did not differ from commercial products in terms of the dissolution property on bovine pulpal tissue ( > 0.05). Moreover, the antibacterial effect of this solution on did not differ from that of the commercial products ( > 0.05). In addition, our biocompatibility analysis demonstrated no difference among the tested solutions ( > 0.05).
According to the results of all properties tested, TCA 3.5% + 1/6 Buffer-1 could be considered an option for NaOCl irrigation with the benefit of no detectable chlorine odor.
本研究旨在开发一种无氯气味的用于根管冲洗的次氯酸盐溶液配方。在细胞培养中评估了该溶液的抗菌效果、组织溶解功效和细胞毒性，并与市售次氯酸钠（NaOCl）溶液进行了比较。
使用三氯异氰尿酸（TCA）作为溶液中次氯酸根离子的来源。评估了NaOCl冲洗剂的所有所需特性，并与目前使用的原始2.5%NaOCl溶液的特性进行了比较。
我们的结果显示，3.5%TCA + 1/6 Buffer-1溶液通过了短期稳定性测试。此外，三名独立观察者均未检测到氯气气味。在4周的孵育期内，次氯酸根离子含量和pH值保持稳定。新溶液在对牛牙髓组织的溶解特性方面与市售产品无差异（>0.05）。此外，该溶液对……的抗菌效果与市售产品无差异（>0.05）。此外，我们的生物相容性分析表明，受试溶液之间无差异（>0.05）。
根据所有测试特性的结果，3.5%TCA + 1/6 Buffer-1可被视为NaOCl冲洗的一种选择，其优点是无明显氯气味。
