转铁蛋白受体 1 和血管内皮生长因子是骨肉瘤的预后因素。
Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma.
机构信息
Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, 050011, Hebei, People's Republic of China.
Department of Pediatrics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, 050011, Hebei, People's Republic of China.
出版信息
J Orthop Surg Res. 2019 Sep 4;14(1):296. doi: 10.1186/s13018-019-1301-z.
BACKGROUND
Osteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we investigated the potential of transferrin receptor-1 (TfR1) and vascular endothelial growth factor (VEGF) as prognostic markers of osteosarcoma.
METHODS
TfR1 and VEGF in osteosarcoma samples from a cohort of 53 osteosarcoma patients were detected by immunohistochemistry analysis. The correlation of TfR1 and VEGF levels with clinicopathological parameters was analyzed by Pearson chi-square and Spearman-rho tests. Overall patient survival was analyzed by the Kaplan-Meier method.
RESULTS
We found that TfR1 and VEGF expression levels were low in 20.8% and 18.9%; modest in 35.8% and 35.8%; and high in 43.4% and 45.3% of osteosarcoma patients, respectively. TfR1 and VEGF expression was significantly correlated to histologic grade, Enneking stage, and distant metastasis. TfR1 expression was significantly correlated to VEGF expression and both TfR1 expression and VEGF expression were correlated to shorter overall survival.
CONCLUSIONS
TfR1 and VEGF are potential prognostic factors for osteosarcoma.
背景
骨肉瘤具有侵袭性，预后生物标志物对于预测手术和化疗的结果非常重要。在这里，我们研究了转铁蛋白受体 1（TfR1）和血管内皮生长因子（VEGF）作为骨肉瘤预后标志物的潜力。
方法
通过免疫组织化学分析检测了来自 53 例骨肉瘤患者队列的骨肉瘤样本中的 TfR1 和 VEGF。通过 Pearson chi-square 和 Spearman-rho 检验分析 TfR1 和 VEGF 水平与临床病理参数的相关性。通过 Kaplan-Meier 方法分析总患者生存率。
结果
我们发现，TfR1 和 VEGF 的表达水平分别为 20.8%和 18.9%（低）、35.8%和 35.8%（适度）和 43.4%和 45.3%（高）。TfR1 和 VEGF 的表达与组织学分级、Enneking 分期和远处转移显著相关。TfR1 表达与 VEGF 表达显著相关，TfR1 表达和 VEGF 表达均与总生存期较短相关。
结论
TfR1 和 VEGF 是骨肉瘤的潜在预后因素。
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