使用MSmetrix进行脑容量测量的洲际验证。
Intercontinental validation of brain volume measurements using MSmetrix.
作者信息
Finkelsztejn Alessandro, Fragoso Yara Dadalti, Bastos Eder Amaral, Duarte Juliana Avila, Varela Juliana Santos, Houbrechts Ruben, Sima Diana, Van Hecke Wim
机构信息
1 Department of Neurology, Hospital de Clinicas de Porto Alegre, Brazil.
2 Department of Neurology, Universidade Metropolitana de Santos, Brazil.
出版信息
Neuroradiol J. 2018 Apr;31(2):147-149. doi: 10.1177/1971400917721521. Epub 2017 Jul 21.
Background Brain volume assessment has become an important outcome within research and treatment of multiple sclerosis (MS). MSmetrix (Icometrix) has been developed specifically for patients with MS. The original healthy, 'normal' population used for determination of the acceptable brain volume data consisted mainly of Europeans. Methods In the present study, results from 295 completely normal magnetic resonance imaging scans from Brazilian subjects were plotted against the original results in MSmetrix. Results With regard to whole brain volume, only 2% of the healthy adult subjects from Brazil were below the 5th percentile of the graph, and for grey matter volume, only 3% of the subjects were below the 5th percentile of MSmetrix standards. Conclusion MSmetrix may be used across different populations.
背景
脑容量评估已成为多发性硬化症（MS）研究和治疗中的一项重要结果指标。MSmetrix（Icometrix公司）是专门为MS患者开发的。用于确定可接受脑容量数据的最初健康“正常”人群主要由欧洲人组成。方法：在本研究中，将295例来自巴西受试者的完全正常的磁共振成像扫描结果与MSmetrix中的原始结果进行对比。结果：就全脑容量而言，来自巴西的健康成年受试者中只有2%低于该图表的第5百分位数，而对于灰质体积，只有3%的受试者低于MSmetrix标准的第5百分位数。结论：MSmetrix可用于不同人群。
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