季铵化羧甲基壳聚糖/有机蒙脱土纳米复合材料作为一种新型的抗皮肤老化化妆品成分。

Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging.

机构信息

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China; Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China.

出版信息

Carbohydr Polym. 2017 Oct 1;173:100-106. doi: 10.1016/j.carbpol.2017.05.088. Epub 2017 May 31.

DOI:10.1016/j.carbpol.2017.05.088

PMID:28732847

Abstract

It is of technical and economic importance to develop an effective cosmetic ingredient against skin aging through low-cost and facile production. This study developed a polymer/layered silicate nanocomposite as cosmetic ingredient against skin aging. Firstly, quaternized carboxymethyl chitosan (QCMC)/organic montmorillonite (OMMT) nanocomposite (QCOM) was fabricated via solution-induced intercalation. QCOM with different mass ratios of QCMC to OMMT were studied by various characterizations as well as moisture-adsorption and retention activities and UV-protection capacity. QCOM was then added into a cosmetic formulation to prepare a cosmetic cream. And the evaluation of its efficacy about skin care was conducted. The results showed that the optimal QCOM had better moisture-adsorption and retention behaviors than hyaluronic acid, and QCOM solution displayed good UV-protection ability. Furthermore, the QCOM-containing cosmetic cream meets the hygienic standard for cosmetics; it has negligible dermal irritation and a prominent moisture-retention efficacy on human stratum corneum.

摘要

通过低成本、简便的生产方法开发有效的抗衰老化妆品成分具有技术和经济意义。本研究开发了一种聚合物/层状硅酸盐纳米复合材料作为化妆品抗衰老成分。首先，通过溶液插层法制备了季铵化羧甲基壳聚糖（QCMC）/有机蒙脱土（OMMT）纳米复合材料（QCOM）。通过各种特性研究、吸湿性和保持活性以及紫外线保护能力研究了不同 QCMC 与 OMMT 质量比的 QCOM。然后将 QCOM 添加到化妆品配方中制备化妆品霜，并对其护肤功效进行评价。结果表明，最佳 QCOM 具有比透明质酸更好的吸湿性和保持性，且 QCOM 溶液具有良好的紫外线保护能力。此外，含有 QCOM 的化妆品霜符合化妆品卫生标准；它对人体角质层的皮肤刺激极小，保湿效果显著。