文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

壳聚糖：药物递送和生物医学应用中的一种潜在生物聚合物。

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications.

作者信息

Desai Nimeet, Rana Dhwani, Salave Sagar, Gupta Raghav, Patel Pranav, Karunakaran Bharathi, Sharma Amit, Giri Jyotsnendu, Benival Derajram, Kommineni Nagavendra

机构信息

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, India.

National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India.

出版信息

Pharmaceutics. 2023 Apr 21;15(4):1313. doi: 10.3390/pharmaceutics15041313.

DOI:10.3390/pharmaceutics15041313
PMID:37111795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10144389/
Abstract

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.

摘要

壳聚糖是一种由几丁质衍生而来的具有生物相容性和可生物降解性的多糖，已成为一种在药物递送和生物医学应用方面颇具前景的材料。不同的几丁质和壳聚糖提取技术可以生产出具有独特性能的材料，这些材料还可以进一步改性以增强其生物活性。基于壳聚糖的药物递送系统已被开发用于各种给药途径，包括口服、眼科、透皮、鼻腔和阴道给药，从而实现药物的靶向和持续释放。此外，壳聚糖已被用于众多生物医学应用，如骨再生、软骨组织再生、心脏组织再生、角膜再生、牙周组织再生和伤口愈合。此外，壳聚糖还被用于基因递送、生物成像、疫苗接种和药妆应用。人们已开发出改性壳聚糖衍生物以改善其生物相容性并增强其性能，从而产生了在各种生物医学应用中具有广阔前景的创新材料。本文总结了壳聚糖及其在药物递送和生物医学科学中的应用的最新研究成果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/2d8ce0a1c757/pharmaceutics-15-01313-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/dc30e0bd4159/pharmaceutics-15-01313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/f1fd0e21789b/pharmaceutics-15-01313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/62b1425cbfa4/pharmaceutics-15-01313-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/fe0045b90a78/pharmaceutics-15-01313-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/9fed3d87c320/pharmaceutics-15-01313-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/4764cc9ee701/pharmaceutics-15-01313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/be1ac319176f/pharmaceutics-15-01313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/aa23b14b6fdb/pharmaceutics-15-01313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/e20c6180042a/pharmaceutics-15-01313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/96e68a47d82b/pharmaceutics-15-01313-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/d3a3ff31c75e/pharmaceutics-15-01313-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/0b97b98ca351/pharmaceutics-15-01313-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/9422109e4ced/pharmaceutics-15-01313-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/f36b93338435/pharmaceutics-15-01313-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/bbb704032c79/pharmaceutics-15-01313-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/cbe8dd9911ba/pharmaceutics-15-01313-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/194a9e8bea62/pharmaceutics-15-01313-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/153af38178fb/pharmaceutics-15-01313-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/2ebc5bce124d/pharmaceutics-15-01313-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/2d8ce0a1c757/pharmaceutics-15-01313-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/dc30e0bd4159/pharmaceutics-15-01313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/f1fd0e21789b/pharmaceutics-15-01313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/62b1425cbfa4/pharmaceutics-15-01313-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/fe0045b90a78/pharmaceutics-15-01313-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/9fed3d87c320/pharmaceutics-15-01313-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/4764cc9ee701/pharmaceutics-15-01313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/be1ac319176f/pharmaceutics-15-01313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/aa23b14b6fdb/pharmaceutics-15-01313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/e20c6180042a/pharmaceutics-15-01313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/96e68a47d82b/pharmaceutics-15-01313-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/d3a3ff31c75e/pharmaceutics-15-01313-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/0b97b98ca351/pharmaceutics-15-01313-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/9422109e4ced/pharmaceutics-15-01313-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/f36b93338435/pharmaceutics-15-01313-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/bbb704032c79/pharmaceutics-15-01313-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/cbe8dd9911ba/pharmaceutics-15-01313-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/194a9e8bea62/pharmaceutics-15-01313-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/153af38178fb/pharmaceutics-15-01313-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/2ebc5bce124d/pharmaceutics-15-01313-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a2/10144389/2d8ce0a1c757/pharmaceutics-15-01313-g019.jpg

相似文献

[1]
Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications.

Pharmaceutics. 2023-4-21

[2]
Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review.

Z Naturforsch C J Biosci. 2024-5-27

[3]
Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing.

Mar Drugs. 2022-7-17

[4]
Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields.

Polymers (Basel). 2024-5-10

[5]
Chitosan scaffolds: Expanding horizons in biomedical applications.

Carbohydr Polym. 2024-1-1

[6]
Novel chitin and chitosan nanofibers in biomedical applications.

Biotechnol Adv. 2010

[7]
Chitosan-Based Biomaterials for Tissue Regeneration.

Pharmaceutics. 2023-3-1

[8]
Chitosan biomaterials application in dentistry.

Int J Biol Macromol. 2020-11-1

[9]
Chitosan as excellent bio-macromolecule with myriad of anti-activities in biomedical applications - A review.

Int J Biol Macromol. 2024-2

[10]
Chitin and chitosan: biopolymers for wound management.

Int Wound J. 2017-8-10

引用本文的文献

[1]
Effect of Recombinant NGF Encapsulated in Chitosan on Rabbit Sperm Traits and Main Metabolic Pathways.

Biology (Basel). 2025-8-1

[2]
Next-Generation Wound Healing Materials: Role of Biopolymers and Their Composites.

Polymers (Basel). 2025-8-19

[3]
Baicalein-Loaded Chitosan Films for Local Treatment of Oral Infections.

Polymers (Basel). 2025-8-8

[4]
Chitosan Nanoparticles Loaded with Polyphenols for Cosmeceutical Applications: A State-of-the-Art Review.

Pharmaceutics. 2025-8-18

[5]
Physicochemical and Biological Properties of Quercetin-Loaded Low-Molecular-Weight Chitosan Nanoparticles Derived from Larvae and Crustacean Sources: A Comparative Study.

Pharmaceutics. 2025-8-5

[6]
Biocompatible Natural Polymer-Based Amorphous Solid Dispersion System Improving Drug Physicochemical Properties, Stability, and Efficacy.

Polymers (Basel). 2025-7-28

[7]
Polymeric Composite Thin Films Deposited by Laser Techniques for Antimicrobial Applications-A Short Overview.

Polymers (Basel). 2025-7-24

[8]
Transfection Technologies for Next-Generation Therapies.

J Clin Med. 2025-8-5

[9]
Hydrogel Conjugation: Engineering of Hydrogels for Drug Delivery.

Pharmaceutics. 2025-7-10

[10]
Advanced Bioactive Polymers and Materials for Nerve Repair: Strategies and Mechanistic Insights.

J Funct Biomater. 2025-7-9

本文引用的文献

[1]
Chitosan Based Materials in Cosmetic Applications: A Review.

Molecules. 2023-2-15

[2]
In Vitro Anti-HIV-1 Activity of Chitosan Oligomers -Conjugated with Asparagine and Glutamine.

BioTech (Basel). 2023-2-8

[3]
Asymmetric wettable polycaprolactone-chitosan/chitosan oligosaccharide nanofibrous membrane as antibacterial dressings.

Carbohydr Polym. 2023-3-15

[4]
Drug/bioactive eluting chitosan composite foams for osteochondral tissue engineering.

Int J Biol Macromol. 2023-2-28

[5]
Enhanced Immune Responses to Mucosa by Functionalized Chitosan-Based Composite Nanoparticles as a Vaccine Adjuvant for Intranasal Delivery.

ACS Appl Mater Interfaces. 2022-11-30

[6]
Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone.

Pharmaceuticals (Basel). 2022-9-28

[7]
Chitosan on the surface of nanoparticles for enhanced drug delivery: A comprehensive review.

J Control Release. 2022-11

[8]
In vitro and ex vivo models for evaluating vaginal drug delivery systems.

Adv Drug Deliv Rev. 2022-12

[9]
A dual-responsive polydopamine-modified hydroxybutyl chitosan hydrogel for sequential regulation of bone regeneration.

Carbohydr Polym. 2022-12-1

[10]
Overcoming skin barriers through advanced transdermal drug delivery approaches.

J Control Release. 2022-11

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索