用于药物递送系统的细菌纤维素和明胶基水凝胶复合材料的合成与表征
Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems.
作者信息
Treesuppharat W, Rojanapanthu P, Siangsanoh C, Manuspiya H, Ummartyotin S
机构信息
Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Patumtani 12120, Thailand.
Materials and Textile Technology, Faculty of Science and Technology, Thammasat University, Patumtani 12120, Thailand.
出版信息
Biotechnol Rep (Amst). 2017 Jul 6;15:84-91. doi: 10.1016/j.btre.2017.07.002. eCollection 2017 Sep.
Bacterial cellulose and gelatin were successfully used to develop a hydrogel composite material. Hydrogel was synthesized by copolymerization between bacterial cellulose and gelatin. Scanning electron microscopy (SEM) images showed that the bacterial cellulose chain was uniform in size and shape. Glutaraldehyde was employed as a crosslinking agent. H-bonds were formed via the reaction between the amine and hydroxyl groups, which were the functional groups of the gelatin and bacterial cellulose, respectively. The hydrogel composite presented excellent properties in terms of its thermal stability, chemical resistance, and mechanical properties. Moreover, the swelling ratio of the hydrogel network, in water, was estimated to be 400-600%. Importantly, the hydrogel composite developed during this study is considered a good candidate for drug-delivery systems.
细菌纤维素和明胶被成功用于开发一种水凝胶复合材料。水凝胶是通过细菌纤维素和明胶之间的共聚反应合成的。扫描电子显微镜（SEM）图像显示，细菌纤维素链的尺寸和形状均匀。戊二醛用作交联剂。通过胺基和羟基之间的反应形成氢键，它们分别是明胶和细菌纤维素的官能团。该水凝胶复合材料在热稳定性、耐化学性和机械性能方面表现出优异的性能。此外，该水凝胶网络在水中的溶胀率估计为400-600%。重要的是，本研究中开发的水凝胶复合材料被认为是药物递送系统的良好候选材料。
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