Weise K, Kretzschmar L, John S M, Hamm H
Department of Dermatology, University of Münster, Germany.
Dermatology. 1996;192(2):129-33. doi: 10.1159/000246337.
Topical immunotherapy of alopecia areata (AA) is an effective but time-consuming treatment with unknown long-term risks.
The purpose of this study was to identify criteria which allow a selection of patients with a good prognosis for topical immunotherapy with diphencyprone.
The anamnestic and clinical data of 50 successfully and 55 unsuccessfully treated patients were compared by the Mann-Whitney test.
Five factors were found to be of prognostic significance: type of AA (p < or = 0.001), presence of nail changes (p < or = 0.001), duration of AA before treatment (p < or = 0.005), age at onset (p < or = 0.01) and association with atopic eczema (p < or = 0.02).
A selection of AA patients who are likely to respond to topical immunotherapy is possible on the basis of anamnestic and clinical data.
斑秃（AA）的局部免疫疗法是一种有效但耗时的治疗方法，其长期风险尚不清楚。
本研究的目的是确定可用于选择对二苯环丙烯酮局部免疫疗法预后良好的患者的标准。
通过Mann-Whitney检验比较50例治疗成功和55例治疗失败患者的既往史和临床数据。
发现五个因素具有预后意义：斑秃类型（p≤0.001）、甲改变的存在（p≤0.001）、治疗前斑秃持续时间（p≤0.005）、发病年龄（p≤0.01）以及与特应性湿疹的关联（p≤0.02）。
根据既往史和临床数据，可以选择可能对局部免疫疗法有反应的斑秃患者。
