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对乙醇偏好或耐受性不同的大鼠品系大脑中儿茶酚胺代谢酶

Enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol.

作者信息

Pispa J P, Huttunen M O, Sarviharju M, Ylikahri R

出版信息

Alcohol Alcohol. 1986;21(2):181-4.

PMID:2874817
Abstract

The activities of the catecholamine-synthesizing and inactivating enzymes were determined in whole brains of two pairs of rat strains differing in their genetically-determined behavioural responses to ethanol. The alcohol-tolerant (AT) rats did not show any significant differences in enzyme activities when compared with the non-tolerant (ANT) strain. The activity of tyrosine hydroxylase was found to be significantly higher in brains of the alcohol-preferring (AA) rats, than in those of the alcohol-non-preferring (ANA) strain.

摘要

在两对对乙醇具有不同遗传决定行为反应的大鼠品系的全脑中，测定了儿茶酚胺合成和失活酶的活性。与不耐受（ANT）品系相比，耐酒精（AT）大鼠的酶活性没有显著差异。发现嗜酒（AA）大鼠大脑中酪氨酸羟化酶的活性显著高于不嗜酒（ANA）品系大鼠大脑中的活性。

相似文献

1
Enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol.对乙醇偏好或耐受性不同的大鼠品系大脑中儿茶酚胺代谢酶
Alcohol Alcohol. 1986;21(2):181-4.
2
Effects of reserpine on activities and amounts of tyrosine hydroxylase and dopamine-beta-hydroxylase in catecholamine neuronal systems in rat brain.利血平对大鼠脑内儿茶酚胺神经元系统中酪氨酸羟化酶和多巴胺-β-羟化酶活性及含量的影响。
J Pharmacol Exp Ther. 1975 Jun;193(3):775-84.
3
Determinants of alcohol preference in the AA and ANA rat lines selected for differential ethanol intake.为不同乙醇摄入量而选育的AA和ANA大鼠品系中酒精偏好的决定因素。
Alcohol Alcohol Suppl. 1991;1:115-20.
4
The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys.长期给予血管加压素对大鼠脑和肾中儿茶酚胺水平及代谢的影响。
Acta Physiol Pol. 1976 May-Jun;27(3):259-64.
5
Comparative effects of ethanol and malnutrition on the development of catecholamine neurons: changes in specific activities of enzymes.乙醇和营养不良对儿茶酚胺神经元发育的比较影响：酶的比活性变化
J Neurochem. 1980 Feb;34(2):297-304. doi: 10.1111/j.1471-4159.1980.tb06596.x.
6
Regulation of catecholamine turnover by variations of enzyme levels.通过酶水平变化对儿茶酚胺周转的调节。
Pharmacol Rev. 1972 Jun;24(2):225-32.
7
Difficulties in comparing catecholamine-related enzymes from the brains of schizophrenics and controls.比较精神分裂症患者和对照组大脑中儿茶酚胺相关酶的困难。
Biol Psychiatry. 1978 Jun;13(3):317-34.
8
[Cerebral catecholamines in experimental excessive emotional stress].[实验性过度情绪应激中的脑儿茶酚胺]
Usp Fiziol Nauk. 1981 Apr-Jun;12(2):67-90.
9
Substance P, neurotensin, enkephalin, and catecholamine-synthesizing enzymes: light microscopic localizations compared with autoradiographic label in solitary efferents to the rat parabrachial region.P物质、神经降压素、脑啡肽和儿茶酚胺合成酶：与大鼠臂旁核孤立传出纤维放射自显影标记相比的光镜定位。
J Comp Neurol. 1984 Jul 1;226(3):434-47. doi: 10.1002/cne.902260311.
10
[The effect of substance P on catecholamine level and activity of enzymes for their synthesis in the brain of chronically alcoholized rats].
Biull Eksp Biol Med. 1994 Jul;118(7):46-8.

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.针对酒精滥用的药物开发的动物模型：神经生物学和药理学的有效性。
Pharmacol Biochem Behav. 2012 Nov;103(1):119-55. doi: 10.1016/j.pbb.2012.07.007. Epub 2012 Jul 25.
2
The AA and ANA rat lines, selected for differences in voluntary alcohol consumption.AA和ANA大鼠品系，是根据自愿酒精摄入量的差异选择出来的。
Experientia. 1989 Sep 15;45(9):798-805. doi: 10.1007/BF01954055.
3
Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice.
肝脏色氨酸吡咯酶。酒精偏好型C57BL小鼠大脑中5-羟色胺浓度降低的一个主要决定因素。
Biochem J. 1989 Dec 1;264(2):597-9. doi: 10.1042/bj2640597.