van Tilburg Bernardes Erik, Lewenza Shawn, Reckseidler-Zenteno Shauna
Department of Microbiology, Immunology, and Infectious Diseases Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Faculty of Science and Technology, Athabasca University, Athabasca, Alberta, Canada T9S 3A3.
Postdoc J. 2015 Jun;3(6):36-49. doi: 10.14304/surya.jpr.v3n6.5.
This review will focus on strategies to develop new treatments that target the biofilm mode of growth and that can be used to treat biofilm infections. These approaches aim to reduce or inhibit biofilm formation, or to increase biofilm dispersion. Many antibiofilm compounds are not bactericidal but render the cells in a planktonic growth state, which are more susceptible to antibiotics and more easily cleared by the immune system. Novel compounds are being developed with antibiofilm activity that includes antimicrobial peptides, natural products, small molecules and polymers. Bacteriophages are being considered for use in treating biofilms, as well as the use of enzymes that degrade the extracellular matrix polymers to dissolve biofilms. There is great potential in these new approaches for use in treating chronic biofilm infections.
本综述将聚焦于开发针对生物膜生长模式的新疗法的策略，这些疗法可用于治疗生物膜感染。这些方法旨在减少或抑制生物膜形成，或促进生物膜分散。许多抗生物膜化合物并无杀菌作用，但能使细胞处于浮游生长状态，而处于这种状态的细胞更容易受到抗生素的作用，也更容易被免疫系统清除。目前正在研发具有抗生物膜活性的新型化合物，包括抗菌肽、天然产物、小分子和聚合物。噬菌体正被考虑用于治疗生物膜，同时也在考虑使用能降解细胞外基质聚合物以溶解生物膜的酶。这些新方法在治疗慢性生物膜感染方面具有巨大潜力。
