Schell Jace, Betts Nancy M, Foster Megan, Scofield R Hal, Basu Arpita
Department of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USA.
Food Funct. 2017 Sep 20;8(9):3083-3090. doi: 10.1039/c7fo00900c.
Recent research supports a favorable role of cranberries on cardiometabolic health. Postprandial metabolism, especially hyperglycemia, has been shown to be an independent cardiovascular risk and few clinical studies have reported the role of berries in improving postprandial dysmetabolism. We investigated the postprandial effects of dried cranberries following a high-fat breakfast challenge in obese participants with type 2 diabetes (T2DM), in a randomized crossover trial. Blood draw and vascular measurements were conducted at fasting, 1, 2 and 4 hours (h), following the consumption of a fast-food style high-fat breakfast (70 g fat, 974 kcal) with or without cranberries (40 g). Analyses of our data (n = 25; BMI (kg m) (mean ± s.d.) = 39.5 ± 6.5; age (years) = 56 ± 6) revealed that postprandial increases in glucose were significantly lower in the cranberry vs. control at 2 & 4 h (p < 0.05). No significant differences were noted in insulin, insulin resistance evaluated by homeostasis model assessment, lipid profiles and blood pressure between the cranberry and control groups. Among the biomarkers of inflammation and oxidation, postprandial serum interleukin-18 and malondialdehyde were significantly lower at 4 h, and serum total nitrite was higher at 2 h in the cranberry vs. control group (all p < 0.05). No effects were noted on C-reactive protein or interlukin-6. Overall, dietary cranberries had notable effects in improving high-fat breakfast induced postprandial glucose and selected biomarkers of inflammation and oxidation in participants with T2DM. These findings provide evidence that adding whole cranberries to a high-fat meal may improve postprandial blood glucose management and warrant further investigation.
近期研究支持蔓越莓对心脏代谢健康具有有益作用。餐后代谢，尤其是高血糖，已被证明是一种独立的心血管风险因素，且很少有临床研究报道浆果在改善餐后代谢紊乱方面的作用。在一项随机交叉试验中，我们研究了干蔓越莓对患有2型糖尿病（T2DM）的肥胖参与者在高脂早餐挑战后的餐后影响。在食用含或不含蔓越莓（40克）的快餐式高脂早餐（70克脂肪，974千卡）后，于空腹、1小时、2小时和4小时进行采血及血管测量。对我们的数据（n = 25；体重指数（kg/m²）（均值±标准差）= 39.5 ± 6.5；年龄（岁）= 56 ± 6）分析显示，在2小时和4小时时，蔓越莓组餐后血糖升高幅度显著低于对照组（p < 0.05）。蔓越莓组与对照组在胰岛素、通过稳态模型评估的胰岛素抵抗、血脂谱和血压方面未观察到显著差异。在炎症和氧化生物标志物中，与对照组相比，蔓越莓组餐后血清白细胞介素-18和丙二醛在4小时时显著降低，血清总亚硝酸盐在2小时时升高（均p < 0.05）。未观察到对C反应蛋白或白细胞介素-6有影响。总体而言，食用蔓越莓对改善T2DM参与者高脂早餐诱导的餐后血糖以及选定的炎症和氧化生物标志物有显著作用。这些发现提供了证据，表明在高脂餐中添加整颗蔓越莓可能改善餐后血糖管理，值得进一步研究。
