National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No. 29 Nanwei Road, Beijing 100050, China.
Nutrients. 2017 Jul 27;9(8):811. doi: 10.3390/nu9080811.
Previous studies have showed an inverse association between magnesium level and type 2 diabetes, but the results are inconsistent, and the evidence relates only to dietary and serum magnesium. Moreover, it is not certain how these findings are applicable to Asian people. This study was designed to examine the association between toenail magnesium and type 2 diabetes in Chinese adults. The sample was 5683 adults aged 18 years or older from the 2009 China Health and Nutrition Survey. We used hemoglobin A1c equal to or greater than 6.5% as the diagnostic criterion for type 2 diabetes. Inductively coupled plasma-mass spectrometry determined toenail magnesium. Mean toenail magnesium in participants with and without type 2 diabetes was 263.0 ± 170.9 and 282.3 ± 191.9 micrograms per gram, respectively. The multivariable-adjusted odds ratio for type 2 diabetes comparing the highest to the lowest quartile of toenail magnesium was 0.72 (95% confidence interval, 0.52-0.99). We found a statistically significant interaction between toenail magnesium and geographic region on the prevalence of type 2 diabetes ( for interaction = 0.009). Our findings suggest that toenail magnesium is inversely associated with the prevalence of type 2 diabetes. Promoting the intake of magnesium-rich foods may bring considerable benefits for the prevention of type 2 diabetes, especially in those at high risk.
先前的研究表明镁的水平与 2 型糖尿病之间呈负相关，但结果不一致，且证据仅与饮食和血清镁有关。此外，这些发现如何适用于亚洲人群尚不确定。本研究旨在探讨中国成年人趾甲镁与 2 型糖尿病之间的关系。样本来自 2009 年中国健康与营养调查的 5683 名 18 岁及以上的成年人。我们将血红蛋白 A1c 等于或大于 6.5%作为 2 型糖尿病的诊断标准。电感耦合等离子体质谱法测定趾甲镁。患有和未患有 2 型糖尿病的参与者的平均趾甲镁分别为 263.0 ± 170.9 和 282.3 ± 191.9 微克/克。趾甲镁最高四分位数与最低四分位数相比，2 型糖尿病的多变量调整比值比为 0.72（95%置信区间，0.52-0.99）。我们发现趾甲镁与地理区域之间存在统计学显著的交互作用（交互作用=0.009）。我们的研究结果表明，趾甲镁与 2 型糖尿病的患病率呈负相关。促进富含镁的食物的摄入可能会为预防 2 型糖尿病带来相当大的益处，尤其是在高危人群中。
