Waddington J L, Youssef H A
Am J Psychiatry. 1986 Sep;143(9):1162-5. doi: 10.1176/ajp.143.9.1162.
Factors associated with the emergence or nonemergence of involuntary movements (tardive dyskinesia) during long-term neuroleptic treatment were investigated in an atypical, isolated population of 31 schizophrenic inpatients with an unusually high prevalence of this syndrome. Patients with involuntary movements could not be distinguished from those without such movements by general characteristics or conventional indices of neuroleptic or anticholinergic treatment. However, they were more likely to show either marked cognitive dysfunction or muteness. These findings support the proposal that, at least in schizophrenia, subtle organic changes may contribute to vulnerability to the emergence of involuntary movements.
在一个非典型的、孤立的31名精神分裂症住院患者群体中，对长期使用抗精神病药物治疗期间不自主运动（迟发性运动障碍）出现或未出现的相关因素进行了调查，该综合征在这个群体中的患病率异常高。有不自主运动的患者与没有此类运动的患者，无法通过抗精神病药物或抗胆碱能治疗的一般特征或传统指标加以区分。然而，他们更有可能表现出明显的认知功能障碍或缄默症。这些发现支持了这样一种观点，即至少在精神分裂症中，细微的器质性变化可能导致易出现不自主运动。
