School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Exercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, China.
Nutrients. 2017 Jul 25;9(8):792. doi: 10.3390/nu9080792.
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19-49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO had lower , but higher than the high VO group ( < 0.05 for all). VO was inversely associated with ( = -0.309, = 0.01) but not with other bacteria. VO also negatively correlated with fat% ( = -0.755, < 0.001), triglycerides ( = -0.274, = 0.021) and leptin ( = -0.574, < 0.001). By contrast, was positively associated with fat% ( = 0.382, = 0.002), dietary fat intake ( = 0.258, = 0.034), triglycerides ( = 0.390, = 0.002) and leptin ( = 0.424, = 0.001), but negatively with carbohydrate intake ( = -0.252, = 0.034) and HDL ( = -0.26, = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO and disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO and , however, appears to be mediated by body fatness.
本研究旨在探讨心肺适能与绝经前女性肠道微生物组成的关系。参与者包括 71 名芬兰绝经前女性（年龄 19-49 岁）。使用流式细胞术、16S rRNA 基因杂交和 DNA 染色分析肠道微生物群。最大摄氧量（VO）通过呼吸气体分析仪评估，身体成分通过生物阻抗仪评估。我们发现，低 VO 组的参与者， 较低，但 较高，与高 VO 组相比（所有 < 0.05）。VO 与 呈负相关（ = -0.309， = 0.01），但与其他细菌无关。VO 也与脂肪百分比（ = -0.755， < 0.001）、甘油三酯（ = -0.274， = 0.021）和瘦素（ = -0.574， < 0.001）呈负相关。相比之下， 与脂肪百分比（ = 0.382， = 0.002）、膳食脂肪摄入量（ = 0.258， = 0.034）、甘油三酯（ = 0.390， = 0.002）和瘦素（ = 0.424， = 0.001）呈正相关，与碳水化合物摄入量（ = -0.252， = 0.034）和高密度脂蛋白（ = -0.26， = 0.028）呈负相关。在调整年龄和饮食摄入后，所有显著关联仍然存在。然而，在调整脂肪百分比后，VO 与 之间的关联消失了。我们的结果表明，心肺适能与肠道微生物组成有关，与年龄和碳水化合物或脂肪摄入无关。然而，VO 与 的关联似乎是由体脂介导的。
