Department of Cardiology, PLA General Hospital, Beijing, China.
Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
Sci Rep. 2017 Jul 31;7(1):6956. doi: 10.1038/s41598-017-07499-9.
Recent studies demonstrated that sinogram affirmed iterative reconstructions (SAFIRE) can produce higher-resolution images with greater robustness for the reduction of various imaging artefacts. Eighty-five patients were prospectively evaluated and underwent a high-pitch spiral acquisition CT scan. In-stent noise, signal-to-noise ratio(SNR), stent-lumen attenuation increase ratio (SAIR), and subjective image quality score were measured and compared between the SAFIRE and Filter back projection (FBP) reconstructions. Conventional coronary angiography served as the standard of reference. In 159 evaluated stents, SAFIRE was superior to FBP with regards to in-stent noise, SNR, SAIR, and image quality score. On per-stent analysis, SAFIRE vs. FBP reconstruction yielded 85% vs. 85%sensitivity, 89% vs. 78%specificity, 73% vs. 57%positive predictive value, 95% vs. 94%negative predictive value, and 0.87 vs. 0.82 area under curve, although these improvements did not reach statistical significance (P > 0.05). However, in the subgroup of small diameter stents (≤3 mm; n = 95), specificity(82% vs. 62%), positive predictive value(66% vs. 50%) and area under curve (0.81 vs. 0.70) improved significantly (P < 0.05) with SAFIRE. SAFIRE image reconstruction can thus improve the evaluation for ISR, especially in smaller stents.
最近的研究表明，正弦图确认迭代重建（SAFIRE）可以产生更高分辨率的图像，并且对减少各种成像伪影具有更强的稳健性。对 85 名患者进行了前瞻性评估，并进行了高螺距螺旋采集 CT 扫描。测量并比较了 SAFIRE 和滤波反投影（FBP）重建之间的支架内噪声、信噪比（SNR）、支架腔衰减增加比（SAIR）和主观图像质量评分。常规冠状动脉造影作为参考标准。在 159 个评估的支架中，SAFIRE 在支架内噪声、SNR、SAIR 和图像质量评分方面优于 FBP。在每个支架的分析中，SAFIRE 与 FBP 重建的灵敏度分别为 85%和 85%，特异性分别为 89%和 78%，阳性预测值分别为 73%和 57%，阴性预测值分别为 95%和 94%，曲线下面积分别为 0.87 和 0.82，尽管这些改善没有达到统计学意义（P > 0.05）。然而，在小直径支架（≤3 毫米；n = 95）亚组中，特异性（82%比 62%）、阳性预测值（66%比 50%）和曲线下面积（0.81 比 0.70）显著提高（P < 0.05）。因此，SAFIRE 图像重建可以改善对支架内再狭窄（ISR）的评估，尤其是在较小的支架中。
