文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

多糖对氧化应激诱导的神经元凋亡的神经保护作用。

Neuroprotective effects of polysaccharides against oxidative stress-induced neuronal apoptosis.

作者信息

Sun Xin-Zhi, Liao Ying, Li Wei, Guo Li-Mei

机构信息

Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Department of Public Security Technology, Railway Police College, Zhengzhou, Henan Province, China.

出版信息

Neural Regen Res. 2017 Jun;12(6):953-958. doi: 10.4103/1673-5374.208590.

DOI:10.4103/1673-5374.208590
PMID:28761429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5514871/
Abstract

polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (HO) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, polysaccharides remarkably suppressed HO-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects.

摘要

多糖对暴露于缺血/再灌注损伤的神经元凋亡具有保护作用，但其机制尚不清楚。本研究的目的是探讨灵芝多糖抗氧化应激诱导的神经元凋亡作用的潜在机制。用过氧化氢（H₂O₂）诱导培养的小脑颗粒细胞凋亡。在这些细胞中，多糖显著抑制H₂O₂诱导的凋亡，降低半胱天冬酶-3、Bax和Bim的表达，并增加Bcl-2的表达。这些结果表明，多糖调节凋亡相关蛋白的表达，抑制氧化应激诱导的神经元凋亡，因此具有显著的神经保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/68949b2066e9/NRR-12-953-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/8055e241a9a8/NRR-12-953-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/6f919ecb62f6/NRR-12-953-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/801e2f5b4b36/NRR-12-953-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/68949b2066e9/NRR-12-953-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/8055e241a9a8/NRR-12-953-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/6f919ecb62f6/NRR-12-953-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/801e2f5b4b36/NRR-12-953-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73a6/5514871/68949b2066e9/NRR-12-953-g005.jpg

相似文献

[1]
Neuroprotective effects of polysaccharides against oxidative stress-induced neuronal apoptosis.

Neural Regen Res. 2017-6

[2]
Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.

Neural Regen Res. 2014-8-1

[3]
The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression.

Tissue Cell. 2021-10

[4]
Exploring the Protective and Reparative Mechanisms of Polysaccharides Against HO-Induced Oxidative Stress in Human Skin Fibroblasts.

Clin Cosmet Investig Dermatol. 2021-10-14

[5]
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.

Int J Oncol. 2004-5

[6]
Protective effects of Ganoderma lucidum triterpenoids on oxidative stress and apoptosis in the spleen of chickens induced by cadmium.

Environ Sci Pollut Res Int. 2019-6-20

[7]
Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress.

Am J Neurodegener Dis. 2016-6-1

[8]
HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression.

Int J Biol Macromol. 2009-11-24

[9]
Structural characterization of polysaccharides after fermentation from and its antioxidant activity in HepG2 cells induced by HO.

Food Chem X. 2023-4-23

[10]
Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.

Acta Pharmacol Sin. 2018-7-10

引用本文的文献

[1]
Evaluation of the Potential Anticonvulsant and Neuroprotective Effects of Ganoderma Lucidum Extract in an Animal Model of Pentylenetetrazol-Induced Seizures.

Neurochem Res. 2025-9-3

[2]
Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells.

Pharmacol Rep. 2025-8-14

[3]
Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Metab Brain Dis. 2025-4-14

[4]
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.

J Agric Food Chem. 2025-3-19

[5]
Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications.

Front Nutr. 2025-1-31

[6]
Tauopathy in AD: Therapeutic Potential of MARK-4.

Curr Alzheimer Res. 2024

[7]
Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review.

Nutrients. 2024-8-13

[8]
Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells.

BMC Complement Med Ther. 2024-4-5

[9]
Polyamines in Edible and Medicinal Fungi from Serbia: A Novel Perspective on Neuroprotective Properties.

J Fungi (Basel). 2023-12-28

[10]
(Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts.

Int J Mol Sci. 2023-12-30

本文引用的文献

[1]
Synthesis of ROS scavenging microspheres from a dopamine containing poly(β-amino ester) for applications for neurodegenerative disorders.

Biomater Sci. 2016-3

[2]
The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia.

Neural Regen Res. 2015-9

[3]
Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats.

Injury. 2015-11

[4]
BH3-only proteins: a 20-year stock-take.

FEBS J. 2015-3

[5]
Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities.

Phytochemistry. 2015-6

[6]
Apoptosis and oxidative stress in neurodegenerative diseases.

J Alzheimers Dis. 2014

[7]
Role of metabolic H2O2 generation: redox signaling and oxidative stress.

J Biol Chem. 2014-2-10

[8]
A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein.

Cell Rep. 2013-12-12

[9]
Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?

PLoS One. 2013-5-13

[10]
Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities.

Int J Biol Macromol. 2013-1-29

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索