Kong Zhe, Wan Xuechao, Zhang Yalong, Zhang Pu, Zhang Yingyi, Zhang Xiaona, Qi Xiaoxiang, Wu Hai, Huang Jianfeng, Li Yao
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, PR China.
Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, PR China.
Biochem Biophys Res Commun. 2017 Nov 25;493(3):1217-1223. doi: 10.1016/j.bbrc.2017.07.162. Epub 2017 Jul 29.
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3' and 5' ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer.
前列腺癌（PCa）是全球男性中最常被诊断出的癌症之一。环状RNA（circRNA）是一类独特的由RNA聚合酶II转录的RNA，其特征是通过外显子或内含子环化将3'和5'末端连接在一起。然而，circRNA在前列腺癌中的分子功能鲜有研究。在本研究中，我们发现与匹配的正常组织相比，circ-SMARCA5在前列腺癌样本中上调。我们还观察到在双氢睾酮（DHT）处理后，circ-SMARCA5的表达显著诱导。功能实验表明，circ-SMARCA5在前列腺癌中通过促进细胞周期和抑制细胞凋亡发挥癌基因作用。我们认为本研究为探索circRNA作为前列腺癌潜在的治疗和预后靶点提供了有用信息。
