Center for Clinical Research and Health Promotion, University of Puerto Rico-MSC, San Juan, PR, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
J Clin Periodontol. 2017 Oct;44(10):989-995. doi: 10.1111/jcpe.12787. Epub 2017 Aug 30.
We assessed the longitudinal association between tooth loss and peripheral arterial disease (PAD) within the Nurses' Health Study.
After excluding participants with prior cardiovascular diseases, 277 of 79,663 women were confirmed as PAD cases during 16 years of follow-up. Number of teeth and recent tooth loss were reported initially in 1992. Subsequent tooth loss was recorded in 1996 and in 2000. We evaluated the associations of baseline number of teeth and recent tooth loss with risk of PAD, adjusting for age, smoking, diabetes, hypertension, high cholesterol, aspirin use, family history of myocardial infarction, BMI, alcohol consumption, physical activity, postmenopausal hormone use, and use of vitamin E, vitamin D, multivitamin and calcium.
Incident tooth loss during follow-up was significantly associated with higher hazard of PAD (HR = 1.31 95% CI: 1.00-1.71). However, the association appeared inverse among never smokers. There was no dose-response relationship between baseline number of teeth and PAD.
Tooth loss showed a modest association with PAD, but no dose-response relationship was observed.
我们评估了护士健康研究中牙齿缺失与外周动脉疾病（PAD）之间的纵向关联。
排除既往心血管疾病患者后，在 16 年的随访中，有 277 名 79663 名女性被确认为 PAD 病例。1992 年首次报告了牙齿数量和近期牙齿缺失情况。1996 年和 2000 年记录了随后的牙齿缺失情况。我们评估了基线牙齿数量和近期牙齿缺失与 PAD 风险的相关性，调整了年龄、吸烟、糖尿病、高血压、高胆固醇、阿司匹林使用、心肌梗死家族史、BMI、饮酒、身体活动、绝经后激素使用以及维生素 E、维生素 D、多种维生素和钙的使用。
随访期间发生的牙齿缺失与 PAD 的更高风险显著相关（HR=1.31，95%CI：1.00-1.71）。然而，这种关联在从不吸烟者中呈反相关。基线牙齿数量与 PAD 之间没有剂量反应关系。
牙齿缺失与 PAD 有一定的关联，但没有观察到剂量反应关系。
