Alyahya Saud, Hamoud Basel, Alqattan Ali, Almasoud Masoud, Almehjan Yousef, Alajmi Rashed, Alhazmi Hesham, Alqaderi Hend
Kuwait Ministry of Health, Kuwait City 15462, Kuwait.
Department of Preventive Dentistry, Faculty of Dental Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
J Clin Med. 2025 Aug 26;14(17):6035. doi: 10.3390/jcm14176035.
(1) Cardiovascular disease (CVD) and edentulism are major public health challenges with shared risk factors and overlapping inflammatory pathways. This study investigates the association between complete tooth loss and CVD. (2) Data were analyzed from the 2015-2018 National Health and Nutrition Examination Survey (NHANES) dataset using Poisson regression analysis to examine the relationship between CVD and complete edentulism, adjusting for age, sex, education, family income-to-poverty ratio, race/ethnicity, diabetes status, and BMI. Of the 11,287 participants, 1763 individuals (15.62%) were completely edentulous, and 9524 (84.38%) retained some or all of their dentition. (3) Individuals with cardiovascular conditions, including myocardial infarction (PR = 1.55; 95% CI: 1.23-1.98), coronary heart disease (PR = 1.44; 95% CI: 1.13-1.85), congestive heart failure (PR = 1.58; 95% CI: 1.22-2.07), and stroke (PR = 1.46; 95% CI: 1.13-1.90), demonstrated a higher prevalence of complete edentulism compared to those without these conditions, after adjusting for key demographic and health-related confounders ( < 0.01). (4) These findings suggest a statistical association between CVD and complete edentulism in U.S. adults. However, due to the cross-sectional nature of this study, causal relationships cannot be inferred, and further longitudinal studies are needed to understand the bidirectional mechanisms between CVD and complete edentulism.
(1) 心血管疾病（CVD）和无牙症是重大的公共卫生挑战，它们具有共同的风险因素和重叠的炎症途径。本研究调查了全口牙齿缺失与心血管疾病之间的关联。(2) 对2015 - 2018年国家健康与营养检查调查（NHANES）数据集进行数据分析，采用泊松回归分析来检验心血管疾病与全口无牙症之间的关系，并对年龄、性别、教育程度、家庭收入与贫困率、种族/民族、糖尿病状况和体重指数进行了调整。在11287名参与者中，1763人（15.62%）全口无牙，9524人（84.38%）保留了部分或全部牙齿。(3) 在调整了关键的人口统计学和健康相关混杂因素后（<0.01），患有心血管疾病的个体，包括心肌梗死（PR = 1.55；95%CI：1.23 - 1.98）、冠心病（PR = 1.44；95%CI：1.13 - 1.85）、充血性心力衰竭（PR = 1.58；95%CI：1.22 - 2.07）和中风（PR = 1.46；95%CI：1.13 - 1.90），与没有这些疾病的个体相比，全口无牙症的患病率更高。(4) 这些发现表明美国成年人中，心血管疾病与全口无牙症之间存在统计学关联。然而，由于本研究的横断面性质，无法推断因果关系，需要进一步的纵向研究来了解心血管疾病与全口无牙症之间的双向机制。
