Choi Jayoung, Kim Do-Yeon, Choue Ryowon, Lim Hyunjung
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea.
Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Korea.
Clin Nutr Res. 2017 Jul;6(3):198-205. doi: 10.7762/cnr.2017.6.3.198. Epub 2017 Jul 28.
Although vitamin C supplements were consumed for health maintenance and fatigue recovery, the effects of high doses of vitamin C supplement remains controversial. Our study performed the effects of 100 mg and 2,000 mg vitamin C supplements on plasma and urinary vitamin C concentration in Korean women. Twenty-four women completed the 4 weeks intervention. Anthropometric data, plasma and urinary vitamin C concentrations, superoxide dismutase activity, thiobarbituric acid reactive substance (TBARS) level, and fatigue severity scale (FSS) were collected, and the statistical analyses compared between- and within-group findings at pre- and post-intervention. Concentrations of vitamin C in plasma and urinary excretion were significantly increased with 100 mg and 2,000 mg of vitamin C supplementation (p < 0.050). TBARS level was decreased significantly with 2,000 mg of vitamin C supplementation (p < 0.050). In addition, FSS was declined significantly in 100 mg of vitamin C supplementation group (p < 0.050). Our result showed that vitamin C supplementation of either 100 mg or 2,000 mg led to an increase in vitamin C concentrations in plasma and vitamin urinary excretion but not statistically significant among groups. TBARS level was decreased in 2,000 mg and FSS was decreased in 100 mg of vitamin C supplementation in Korean women. We suppose that additional clinical trial is needed to examine the effects of vitamin C supplements for a wide range of doses on plasma and urinary vitamin C concentrations in Korean.
尽管人们服用维生素C补充剂是为了维持健康和恢复疲劳，但高剂量维生素C补充剂的效果仍存在争议。我们的研究探讨了100毫克和2000毫克维生素C补充剂对韩国女性血浆和尿液中维生素C浓度的影响。24名女性完成了为期4周的干预。收集了人体测量数据、血浆和尿液中维生素C浓度、超氧化物歧化酶活性、硫代巴比妥酸反应物质（TBARS）水平以及疲劳严重程度量表（FSS），并对干预前后组间和组内的结果进行了统计分析。补充100毫克和2000毫克维生素C后，血浆和尿液中维生素C的浓度显著增加（p < ０.０５０）。补充2000毫克维生素C后，TBARS水平显著降低（p < ０.０５０）。此外，补充100毫克维生素C的组中FSS显著下降（p < ０.０５０）。我们的结果表明，补充100毫克或2000毫克维生素C均可导致血浆中维生素C浓度和尿液中维生素C排泄增加，但组间无统计学显著差异。补充2000毫克维生素C可降低韩国女性的TBARS水平，补充100毫克维生素C可降低FSS。我们认为需要进一步的临床试验来研究不同剂量维生素C补充剂对韩国人血浆和尿液中维生素C浓度的影响。
