用于软骨再生的生物活性玻璃纤维增强聚癸二酸甘油酯基复合材料
Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration.
作者信息
Souza Marina Trevelin, Tansaz Samira, Zanotto Edgar Dutra, Boccaccini Aldo R
机构信息
CeRTEV-Center for Research, Technology and Education in Vitreous Materials, Vitreous Material Laboratory, Department of Materials Engineering, Universidade Federal de São Carlos-UFSCar, 13565905 São Carlos, SP, Brazil.
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.
出版信息
Materials (Basel). 2017 Jan 20;10(1):83. doi: 10.3390/ma10010083.
Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS-bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity.
聚癸二酸甘油酯（PGS）是一种弹性体聚合物，在包括软骨再生在内的生物医学应用中越来越受到关注。然而，其有限的机械性能以及降解副产物可能产生的负面影响限制了PGS在体内的应用。在本研究中，开发并表征了一种新型的PGS-生物活性玻璃纤维（F18）增强复合材料。通过盐沥滤法制备了基于PGS的增强支架，并对其机械性能、降解性能以及与模拟体液接触时的生物活性进行了表征。结果表明，加入基于硅酸盐的生物活性玻璃纤维可使复合材料的拉伸强度提高一倍，调整聚合物的降解性，并改善支架的生物活性。
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