用壳寡糖稳定的抗菌氯化银纳米颗粒用于烧伤愈合
Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns.
作者信息
Kang Yun Ok, Jung Ju-Young, Cho Donghwan, Kwon Oh Hyeong, Cheon Ja Young, Park Won Ho
机构信息
Department of Nano Manufacturing Technology, Nano Convergence Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon 34103, Korea.
Department of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
出版信息
Materials (Basel). 2016 Mar 23;9(4):215. doi: 10.3390/ma9040215.
Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI) exerted by the silver chloride nanoparticles (AgCl NPs) on burn wound healing in a rat model. The CHI-AgCl NPs had a spherical morphology with a mean diameter of 42 ± 15 nm. The burn wound healing of CHI-AgCl NPs ointment was compared with untreated group, Vaseline ointment, and chitosan ointment group. The burn wound treated with CHI-AgCl NPs ointment was completely healed by 14 treatment days, and was similar to normal skin. Particularly, the regenerated collagen density became the highest in the CHI-AgCl NPs ointment group. The CHI-AgCl NPs ointment is considered a suitable healing agent for burn wounds, due to dual antibacterial activity of the AgCl NPs and CHI.
最近，为了开发抗菌剂，人们对许多化合物进行了研究，这些抗菌剂可以防止伤口感染，并促进伤口愈合。为此，合成了用壳寡聚物稳定的新型氯化银纳米颗粒（CHI-AgCl NPs），以研究氯化银纳米颗粒（AgCl NPs）发挥的抗菌壳寡聚物（CHI）对大鼠模型烧伤创面愈合的影响。CHI-AgCl NPs呈球形，平均直径为42±15nm。将CHI-AgCl NPs软膏的烧伤创面愈合情况与未治疗组、凡士林软膏组和壳聚糖软膏组进行比较。用CHI-AgCl NPs软膏治疗的烧伤创面在治疗14天后完全愈合，与正常皮肤相似。特别是，CHI-AgCl NPs软膏组再生胶原密度最高。由于AgCl NPs和CHI的双重抗菌活性，CHI-AgCl NPs软膏被认为是一种适合烧伤创面的愈合剂。
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