Wang Ji, Vermerris Wilfred
Department of Microbiology & Cell Science, IFAS, University of Florida, Cancer/Genetics Research Complex 302, 2033 Mowry Road, Gainesville, FL 32610, USA.
UF Genetics Institute, University of Florida, Gainesville, FL 32610, USA.
Materials (Basel). 2016 Mar 30;9(4):255. doi: 10.3390/ma9040255.
Modern medicine has relied heavily on the availability of effective antibiotics to manage infections and enable invasive surgery. With the emergence of antibiotic-resistant bacteria, novel approaches are necessary to prevent the formation of biofilms on sensitive surfaces such as medical implants. Advances in nanotechnology have resulted in novel materials and the ability to create novel surface topographies. This review article provides an overview of advances in the fabrication of antimicrobial nanomaterials that are derived from biological polymers or that rely on the incorporation of natural compounds with antimicrobial activity in nanofibers made from synthetic materials. The availability of these novel materials will contribute to ensuring that the current level of medical care can be maintained as more bacteria are expected to develop resistance against existing antibiotics.
现代医学在很大程度上依赖于有效的抗生素来控制感染并开展侵入性手术。随着抗生素耐药菌的出现，需要采用新方法来防止生物膜在诸如医用植入物等敏感表面形成。纳米技术的进步带来了新型材料，并具备了创造新型表面形貌的能力。这篇综述文章概述了抗菌纳米材料制备方面的进展，这些材料要么源自生物聚合物，要么依赖于将具有抗菌活性的天然化合物掺入由合成材料制成的纳米纤维中。随着预计会有更多细菌对现有抗生素产生耐药性，这些新型材料的出现将有助于确保维持当前的医疗水平。
