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在慢性阻塞性肺疾病或哮喘的成年患者中,干粉吸入器与压力定量气雾剂吸入器的使用模式:一项观察性比较研究。

Patterns of use of dry powder inhalers versus pressurized metered-dose inhalers devices in adult patients with chronic obstructive pulmonary disease or asthma: An observational comparative study.

机构信息

1 Department of Pharmacy Practice, School of Pharmacy, Lebanese American University, Byblos, Lebanon.

2 School of Pharmacy, Lebanese American University, Byblos, Lebanon.

出版信息

Chron Respir Dis. 2017 Aug;14(3):309-320. doi: 10.1177/1479972316687209. Epub 2017 Feb 24.

Abstract

Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative observational study was conducted at one hospital and 15 community pharmacies in Lebanon. Over a period of 18 months, 246 questionnaires were filled. Patients included were adults with COPD or asthma. Answers were entered into the Statistical Package for Social Sciences software and excel sheet. T-test and correlation were used to analyze the results; 67.8% and 38.4% of those using DPIs and MDIs, respectively, performed the exact technical steps adequately ( p = 0.003, relative risk: 2.134, 95% confidence interval: 0.910-4.842). When compared to MDI, a higher percentage of DPI users found their devices easy to use. Moreover, 81.4% of the MDI users found difficulty in coordinating between pressing the canister and inhaling. Rates of exacerbations were significantly higher in MDIs vs. DPI users (59.4% vs. 21.7%). Overall, 44.31% of patients did not receive education from their healthcare professionals about the devices. A significant number of COPD/asthma adult patients do not use their devices properly. Even though DPIs were significantly easier to use, proper education on the technical use of all types of inhalers is needed.

摘要

许多患有慢性阻塞性肺疾病 (COPD) 和哮喘的患者不能正确使用吸入器,这可能导致疾病控制不佳。本研究旨在评估干粉吸入器 (DPI) 与压力定量吸入器 (MDI) 在黎巴嫩 COPD 或哮喘成年患者中的技术和安全性使用。在黎巴嫩的一家医院和 15 家社区药房同时进行了前瞻性比较观察研究。在 18 个月的时间里,共填写了 246 份问卷。纳入的患者为患有 COPD 或哮喘的成年人。答案被输入到社会科学统计软件和 excel 表中。使用 T 检验和相关性分析来分析结果;分别使用 DPI 和 MDI 的患者中,有 67.8%和 38.4%的患者能够正确执行所有技术步骤(p=0.003,相对风险:2.134,95%置信区间:0.910-4.842)。与 MDI 相比,更高比例的 DPI 用户认为他们的设备易于使用。此外,81.4%的 MDI 用户发现难以协调按下罐和吸入之间的动作。与 DPI 用户相比,MDI 用户的恶化率明显更高(59.4%对 21.7%)。总体而言,44.31%的患者没有从他们的医疗保健专业人员那里获得关于设备的教育。相当数量的 COPD/哮喘成年患者没有正确使用他们的设备。尽管 DPI 使用起来明显更容易,但需要对所有类型吸入器的技术使用进行适当的教育。

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