Kehayias P, Jarmola A, Mosavian N, Fescenko I, Benito F M, Laraoui A, Smits J, Bougas L, Budker D, Neumann A, Brueck S R J, Acosta V M
Department of Physics, Harvard University, Cambridge, 02138, MA, USA.
Center for High Technology Materials, Department of Physics and Astronomy, University of New Mexico, Albuquerque, 87106, NM, USA.
Nat Commun. 2017 Aug 4;8(1):188. doi: 10.1038/s41467-017-00266-4.
Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR studies. We demonstrate NMR spectroscopy of picoliter-volume solutions using a nanostructured diamond chip with dense, high-aspect-ratio nanogratings, enhancing the surface area by 15 times. The nanograting sidewalls are doped with nitrogen-vacancies located a few nanometers from the diamond surface to detect the NMR spectrum of roughly 1 pl of fluid lying within adjacent nanograting grooves. We perform H and F nuclear magnetic resonance spectroscopy at room temperature in magnetic fields below 50 mT. Using a solution of CsF in glycerol, we determine that 4 ± 2 × 10F spins in a 1 pl volume can be detected with a signal-to-noise ratio of 3 in 1 s of integration.Nitrogen vacancy (NV) centres in diamond can be used for NMR spectroscopy, but increased sensitivity is needed to avoid long measurement times. Kehayias et al. present a nanostructured diamond grating with a high density of NV centres, enabling NMR spectroscopy of picoliter-volume solutions.
利用金刚石中氮空位中心的传感器是用于小体积核磁共振（NMR）光谱学的一种很有前景的工具，但灵敏度有限仍然是一个挑战。在此，我们展示了与之前的氮空位和皮升NMR研究相比，浓度灵敏度提高了近两个数量级。我们使用具有密集、高纵横比纳米光栅的纳米结构金刚石芯片，展示了皮升体积溶液的NMR光谱，将表面积提高了15倍。纳米光栅侧壁掺杂有距离金刚石表面几纳米的氮空位，以检测相邻纳米光栅凹槽内约1皮升流体的NMR光谱。我们在低于50 mT的磁场中于室温下进行了氢和氟的核磁共振光谱学研究。使用CsF在甘油中的溶液，我们确定在1皮升体积中4±2×10个氟自旋在1秒积分时间内可以以3的信噪比被检测到。金刚石中的氮空位（NV）中心可用于NMR光谱学，但需要提高灵敏度以避免长时间测量。凯希亚斯等人展示了一种具有高密度NV中心的纳米结构金刚石光栅，实现了皮升体积溶液的NMR光谱学研究。
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