Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan; Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Division of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, Japan; Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Int J Infect Dis. 2017 Oct;63:21-22. doi: 10.1016/j.ijid.2017.07.023. Epub 2017 Aug 2.
The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.
mcr-1 基因编码磷酸乙醇胺转移酶，通过将磷酸乙醇胺转移到脂 A 上赋予对黏菌素的抗性。我们在此描述了日本出现一株携带质粒介导 mcr-1 的耐黏菌素大肠埃希菌临床分离株。该分离株属于 ST5702，疑似来自家畜并传播给人类。这是日本首例报告携带 mcr-1 的临床分离株。
