1Department of Microbiology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
2Department of Nursing, National Center for Child Health and Development, Setagaya-ku, Tokyo 157-8535, Japan.
J Med Microbiol. 2018 Aug;67(8):1047-1049. doi: 10.1099/jmm.0.000793. Epub 2018 Jul 4.
The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and blaNDM-5 genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and blaNDM-5.
mcr-1 基因编码一种磷酸乙醇胺转移酶，通过将磷酸乙醇胺转移到脂 A 上赋予对黏菌素的抗性。本研究描述了一株含有 mcr-1 和 blaNDM-5 基因的耐黏菌素和碳青霉烯类临床分离大肠杆菌的出现，这些基因分别位于 90 和 150 kb 质粒上。该分离株属于 ST132。这是日本首例同时携带 mcr-1 和 blaNDM-5 的临床分离株的报告。
