Taherzade Seyed Dariush, Soleimannejad Janet, Tarlani Aliakbar
School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Pajoohesh Blvd., km 17, Karaj Hwy, P.O. Box 14968-13151, Tehran, Iran.
Nanomaterials (Basel). 2017 Aug 6;7(8):215. doi: 10.3390/nano7080215.
Nanostructures of MIL-100 were synthesized and used as a drug delivery platform for two members of the Tetracycline family. Doxycycline monohydrate (DOX) and Tetracycline hydrochloride (TC) were loaded separately on nano-MIL-100 (nanoparticles of drug@carrier were abbreviated as DOX@MIL-100 and TC@MIL-100). Characterizations were carried out using FT-IR, XRD, BET, DLS, and SEM. The FT-IR spectra revealed that the drugs were loaded into the framework of the carrier. The XRD patterns of DOX@MIL-100 and TC@MIL-100 indicated that no free DOX or TC were present. It could be concluded that the drugs are well dispersed into the pores of nano-MIL-100. The microporosity of the carrier was confirmed by BJH data. BET analysis showed a reduction in the free surface for both DOX@MIL-100 and TC@MIL-100. The release of TC and DOX was investigated, and it was revealed that MIL-100 mediated the drug solubility in water, which in turn resulted in a decrease in the release rate of TC (accelerating in DOX case) without lowering the total amount of released drug. After 48 h, 96 percent of the TC was sustain released, which is an unprecedented amount in comparison with other methods.
合成了MIL-100纳米结构，并将其用作四环素家族两个成员的药物递送平台。分别将多西环素一水合物（DOX）和盐酸四环素（TC）负载到纳米MIL-100上（药物@载体的纳米颗粒缩写为DOX@MIL-100和TC@MIL-100）。使用傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、比表面积分析（BET）、动态光散射（DLS）和扫描电子显微镜（SEM）进行表征。FT-IR光谱显示药物被负载到载体框架中。DOX@MIL-100和TC@MIL-100的XRD图谱表明不存在游离的DOX或TC。可以得出结论，药物很好地分散在纳米MIL-100的孔中。载体的微孔率通过BJH数据得到证实。BET分析表明DOX@MIL-100和TC@MIL-100的自由表面均减少。研究了TC和DOX的释放情况，结果表明MIL-100介导了药物在水中的溶解度，这反过来导致TC释放速率降低（在DOX情况下加速），而不会降低药物的总释放量。48小时后，96%的TC持续释放，与其他方法相比，这是一个前所未有的量。
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