Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Centre for Synthetic Biology and Innovation, Department of Life Sciences, Imperial College London, London, United Kingdom.
Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.00929-17. Print 2017 Oct.
is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant .
耐碳青霉烯肠杆菌科( CRE )是全球主要的抗微生物药物耐药性威胁之一。本研究确定了临床株和相关种属对氯硫酰胺的 MIC 值为 0.008 至 0.5 毫克/升。与现有抗微生物药物耐药性的交叉耐药性未被检测到,表明氯硫酰胺可用于治疗耐药性 。