College of Health & Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Research Department, Sidra Medicine, Doha, Qatar.
J Transl Med. 2023 Jun 6;21(1):364. doi: 10.1186/s12967-023-04230-3.
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has been associated with an increased risk of obesity and diabetes in the offspring. Pregnancy is accompanied by tightly regulated changes in the endocrine, metabolic, immune, and microbial systems, and deviations from these changes can alter the mother's metabolism resulting in adverse pregnancy outcomes and a negative impact on the health of her infant. Maternal microbiomes are significant drivers of mother and child health outcomes, and many microbial metabolites are likely to influence the host health. This review discusses the current understanding of how the microbiota and microbial metabolites may contribute to the development of GDM and how GDM-associated changes in the maternal microbiome can affect infant's health. We also describe microbiota-based interventions that aim to improve metabolic health and outline future directions for precision medicine research in this emerging field.
妊娠期糖尿病（GDM）是一种常见的妊娠并发症，与后代肥胖和糖尿病的风险增加有关。妊娠伴随着内分泌、代谢、免疫和微生物系统的严格调节变化，而这些变化的偏差会改变母亲的新陈代谢，导致不良的妊娠结局，并对她婴儿的健康产生负面影响。母体微生物组是母婴健康结果的重要驱动因素，许多微生物代谢产物可能会影响宿主的健康。本综述讨论了目前对微生物组和微生物代谢产物如何有助于 GDM 发展的理解，以及 GDM 相关的母体微生物组变化如何影响婴儿的健康。我们还描述了旨在改善代谢健康的基于微生物组的干预措施，并概述了这一新兴领域精准医学研究的未来方向。
