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宫内人工授精及精子处理技术在不明原因不孕和男性不育治疗中的作用

ROLE OF INTRA-UTERINE INSEMINATION AND SPERM PREPARATION TECHNIQUES IN TREATMENT OF UNEXPLAINED INFERTILITY AND MALE INFERTILITY.

作者信息

Kumar Sushil, Azgaonkar Hemangi, Awasthi R T, Kapoor Anupam, Srinivas S

机构信息

Classified Specialist, Deptartment of Obstetrics and Gynaecology, INHS Asvini, Mumbai 400 005.

Post Graduate Student, Deptartment of Obstetrics and Gynaecology, INHS Asvini, Mumbai 400 005.

出版信息

Med J Armed Forces India. 2000 Jul;56(3):209-212. doi: 10.1016/S0377-1237(17)30168-5. Epub 2017 Jun 10.

DOI:10.1016/S0377-1237(17)30168-5
PMID:28790709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5532047/
Abstract

Role of intrauterine insemination (IUI) in infertile couples is evaluated. Patients selected for the study belonged to two categories-Unexplained infertility(34 patients) and Male infertility (30 patients). In all the patients selected for IUI ovarian hyperstimulation was carried out with clomiphene citrate. Two techniques of sperm preparation were used - swim-up technique and mono-percoll gradient separation technique. Pregnancy rates of 15.6% per patient and 7% per cycle respectively were achieved which are comparable with other studies. Mono-percoll sperm separation technique was found more effective in treatment of Male infertility (oligo-asthenospermic semen sample).

摘要

评估了宫腔内人工授精（IUI）在不孕夫妇中的作用。入选该研究的患者分为两类——不明原因不孕（34例患者）和男性不育（30例患者）。所有入选IUI的患者均使用枸橼酸氯米芬进行卵巢超刺激。采用了两种精子处理技术——上游技术和单倍 Percoll 梯度分离技术。分别达到了每位患者15.6%和每个周期7%的妊娠率，这与其他研究结果相当。发现单倍 Percoll 精子分离技术在治疗男性不育（少弱精子症精液样本）方面更有效。

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本文引用的文献

1
A Mono-Percoll separation technique improves sperm recovery of normal and male factor specimens when compared with the swim-up technique.与上游法相比，单密度梯度离心分离技术可提高正常和男性因素样本的精子回收率。
Hum Reprod. 1995 Dec;10(12):3195-7. doi: 10.1093/oxfordjournals.humrep.a135886.
2
A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate.一项关于在使用人绝经期促性腺激素或枸橼酸氯米芬刺激的周期中，人工授精与自然性交的前瞻性随机试验。
Fertil Steril. 1993 Mar;59(3):554-9.
3
Percoll semen preparation enhances human oocyte fertilization in male-factor infertility as shown by a randomized cross-over study.一项随机交叉研究表明，Percoll精液制备可提高男性因素不孕症患者的人类卵母细胞受精率。
Hum Reprod. 1993 Sep;8(9):1438-42. doi: 10.1093/oxfordjournals.humrep.a138275.
4
Comparison of direct swim-up, mini-Percoll, and Sephadex G10 separation procedures.直接上游法、微型Percoll法和葡聚糖G10分离程序的比较。
Arch Androl. 1994 Mar-Apr;32(2):157-62. doi: 10.3109/01485019408987781.
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The treatment of infertility by the high intrauterine insemination of husband's washed spermatozoa.
Hum Reprod. 1988 Nov;3(8):939-43. doi: 10.1093/oxfordjournals.humrep.a136822.
6
Nuclear maturity and morphology of human spermatozoa selected by Percoll density gradient centrifugation or swim-up procedure.通过Percoll密度梯度离心法或上游法筛选的人类精子的核成熟度和形态。
J Reprod Fertil. 1988 Nov;84(2):551-6. doi: 10.1530/jrf.0.0840551.
7
Unexplained infertility--the value of Pergonal superovulation combined with intrauterine insemination.不明原因的不孕症——人绝经期促性腺激素超排卵联合宫腔内人工授精的价值
Fertil Steril. 1988 Apr;49(4):602-6. doi: 10.1016/s0015-0282(16)59825-2.
8
Failure of intrauterine insemination in a refractory infertility population.难治性不孕人群中宫内人工授精的失败情况。
Fertil Steril. 1991 Aug;56(2):361-3. doi: 10.1016/s0015-0282(16)54502-6.
9
Mini-Percoll: a new method of semen preparation for IVF in severe male factor infertility.微量 Percoll：严重男性因素不育症体外受精精液制备的新方法。
Hum Reprod. 1990 Nov;5(8):987-9. doi: 10.1093/oxfordjournals.humrep.a137233.
10
Intrauterine insemination after ovarian stimulation as a treatment for subfertility because of subnormal semen: a prospective randomized controlled trial.卵巢刺激后宫腔内人工授精治疗精液异常所致的亚生育力：一项前瞻性随机对照试验
Fertil Steril. 1992 Nov;58(5):995-9. doi: 10.1016/s0015-0282(16)55449-1.

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