Suri Yudhvir
Senior Adviser (Anaesthesiology), Base Hospital, Delhi Cantt-110 010.
Med J Armed Forces India. 2000 Oct;56(4):287-292. doi: 10.1016/S0377-1237(17)30209-5. Epub 2017 Jun 12.
An open randomised, comparative study was planned to evaluate efficacy and tolerability of intramuscular midazolam and oral diazepam for preoperative sedation of patients under anaesthesia. 113 patients [diazepam=57;midazolam=56] of ASA grade I-II; between 18-60 years of age of either sex participated. Greater anxiety relief (p < 0.0001) was observed in the midazolam group compared to the diazepam group. Midazolam produced better clinically acceptable sedation of short duration. Excellent anterograde amnesia was seen with midazolam with lack of recall of intraoperative events during surgery. Cardiovascular stability was seen with both the drugs. Global quality of premedication assessed by the anaesthesiologist was excellent or good with midazolam as compared to satisfactory or poor with diazepam.
计划开展一项开放性随机对照研究,以评估肌肉注射咪达唑仑和口服地西泮用于麻醉下患者术前镇静的疗效和耐受性。113例年龄在18至60岁之间、ASA分级为I-II级的患者(地西泮组=57例;咪达唑仑组=56例)参与了研究,男女不限。与地西泮组相比,咪达唑仑组的焦虑缓解程度更高(p<0.0001)。咪达唑仑产生了更好的、临床可接受的短时间镇静效果。使用咪达唑仑可产生出色的顺行性遗忘,患者在手术期间对术中事件无记忆。两种药物均能维持心血管稳定性。麻醉医生评估的术前用药总体质量方面,咪达唑仑组为优或良,而地西泮组为满意或差。